1 Start
2 Millenium
3 Members
4 Album
5 Common Diseases
6 Mice
7 Volunteer
8 Functional Genomics
9 with Industry
10 Posit. available
11 Res. Grant
12 Publications
13 Terminology
14 Links
15 ASNPs
| |
Last Updated on 05/09/01 16:52
Welcome to HP of "Functional Genomics" Japanese
Homepage 
You are the        visitor.
made public on April 7, 2003.
"Tokushima ASNPs ( )"
database supplies minor allele frequencies of Gene-Centric Even-Spacing Common SNPs in
Japanese and Chinese to select the most efficient SNP markers for the high-efficiency Case-Control
association study.
The idea of "Gene-Centric"
covers 10 kb 5'-upstream and 3'-downstream of the gene. The idea of "Common
SNPs" means the Minor Allele Frequency >= 15% in 46 healthy
Japanese or Chinese subjects. We have uploaded the total number of 91,276
SNPs with minor allele frequency data in 4 populations including Caucasian,
African American, Chinese, and Japanese on Aug. 27, 2005. The list of high
minor allele frequency SNPs commonly present among 4 populations supports the
efficient discovery of the susceptibility SNPs for common diseases.
Division
of Genetic Information is persueing Functional Genomics by Case-control
ssociation studies on diabetes and rheumatoid arthritis with "Even-spacing
common shared SNPs markers newly developed and validated in Japanese", QTL
analysis of diabetic model mice, linkage analysis of inherited metabolic
diseases, and studies using various transgenic mouse models. This division
has already introduced mass-spectometers for proteomic application of functional
genomics. This division collaborates with other 4 regular divisions and 1
visiting division in education and research.
 As
described above、we have developed highly efficient Even-Spacing
Common SNPs Probes for association study. Minor allele frequency of
about 53,000 SNPs are published in our Tokushima
ASNPs database (). Outline is explained in
15
ASNPs.
Common Diseases include diabetes, gout, rheumatoid
arthritis, schizophrenia, dementia, cancer etc. which are the
important target diseases of the 21st century. ........
Division of Genetic Information is one of the three
divisions in Institute for Genome Research. Please click here to
visit IGR homepage.（）
|
