原著論文 （２０１６年）

Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, Maeda T, Nagata Y, Kitanaka A, Mizuno S, Tanaka H, Chiba K, Ito S, Watatani Y, Kakiuchi N, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Itonaga H, Imaizumi Y, Totoki Y, Munakata W, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Masuda K, Minato N, Kashiwase K, Izutsu K, Takaori-Kondo A, Miyazaki Y, Takahashi S, Shibata T, Kawamoto H, Akatsuka Y, Shimoda K, Takeuchi K, Seya T, Miyano S, Ogawa S.
Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers.
Nature. 534:402-406 (2016)

Gomes AC, Hara T, Lim VY, Herndler-Brandstetter D, Nevius E, Sugiyama T, Tani-ichi S, Schlenner S, Richie E, Rodewald H, Flavell RA, Nagasawa T, Ikuta K, Pereira JP.
Hematopoietic stem cell niches produce lineage-instructive signals to control multipotent progenitor differentiation.
Immunity. 45:1219-1231 (2016)

Terashima A, Okamoto K, Nakashima T, Akira S, Ikuta K, Takayanagi H.
Sepsis-induced osteoblast ablation causes immunodeficiency.
Immunity. 44:1434-1443 (2016)

Miyauchi K, Sugimoto-Ishige A, Harada Y, Adachi Y, Usami Y, Kaji T, Inoue K, Hasegawa H, Watanabe T, Hijikata A, Fukuyama S, Maemura T, Okada-Hatakeyama M, Ohara O, Kawaoka Y, Takahashi Y, Takemori T, Kubo M.
Protective neutralizing influenza antibody response in the absence of T follicular helper cells.
Nat Immunol. 17:1447-1458 (2016)

Gil-Cruz C, Perez-Shibayama C, Onder L, Chai Q, Cupovic J, Cheng H, Novkovic M, Lang PA, Geuking MB, McCoy KD, Abe S, Cui G, Ikuta K, Scandella E, Ludewig B.
Fibroblastic reticular cells regulate intestinal inflammation through IL-15-mediated control of group 1 ILCs.
Nat Immunol. 17:1388-1396 (2016)

Moro K, Kabata H, Tanabe M, Koga S, Takeno N, Mochizuki M, Fukunaga K, Asano K, Betsuyaku T, Koyasu S.
Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses.
Nat Immunol. 17(1):76-86 (2016)

Shirakawa K, Yan X, Shinmura K, Endo J, Kataoka M, Katsumata Y, Yamamoto T, Anzai A, Isobe S, Yoshida N, Itoh H, Manabe I, Sekai M, Hamazaki Y, Fukuda K, Minato N, Sano M.
Obesity accelerates T cell senescence in murine visceral adipose tissue.
J Clin Invest. 126:4626-4639 (2016)

Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, Dainichi T, Fukuda S, Kabashima K, Nakaoka S, Bin BH, Kubo M, Ohno H, Hasegawa T, Ohara O, Koseki H, Wakana S, Yoshida H.
Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis.
J Clin Invest. 126:2064-2076 (2016)

Nonaka T, Toda Y, Hiai H, Uemura M, Nakamura M, Yamamoto N, Asato R, Hattori Y, Bessho K, Minato N, Kinoshita K.
Involvement of activation-induced cytidine deaminase in skin cancer development.
J Clin Invest. 126:1367-1382 (2016)

Yokoyama T, Nakatake M, Kuwata T, Couzinet A, Goitsuka R, Tsutsumi S, Aburatani H, Valk PJ, Delwel R, Nakamura T.
MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.
J Clin Invest. 126:1664-1678 (2016)

Domínguez-Hüttinger E, Christodoulides P, Miyauchi K, Irvine AD, Okada-Hatakeyama M, Kubo M, Tanaka RJ.
Mathematical modeling of atopic dermatitis reveals "double switch" mechanisms underlying four common disease phenotypes.
J Allergy Clin Immunol Pract. In press (2016)

Najima Y, Tomizawa-Murasawa M, Saito Y, Watanabe T, Ono R, Ochi T, Suzuki N, Fujiwara H, Ohara O, Shultz LD, Yasukawa M, Ishikawa F.
Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I TG NSG mice.
Blood. 127:722-734 (2016)

Suzuki K, Hayano Y, Nakai A, Furuta F, Noda M.
Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes.
J Exp Med. 213: 2567-2574 (2016)

Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger JM, Kobayashi Y, Inoue J, Akiyama T.
Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator.
J Exp Med. 213:1441-1458 (2016)

*Sugawara R, *Lee E-J, Jang MS, Jeun E-J, Hong C-P, Kim J-H, Park A, Yun CH, Hong S-W, Kim Y-M, Seoh J-Y, Jung YJ, Surh CD, Miyasaka M, **Yang B-G, **Jang MH. (*equal contribution) (**equal contribution)
Small intestinal eosinophils regulate TH17 cells by producing IL-1 receptor antagonist.
J Exp Med. 213:555-567 (2016)

Takeuchi A, Badr Mel S, Miyauchi K, Ishihara C, Onishi R, Guo Z, Sasaki Y, Ike H, Takumi A, Tsuji NM, Murakami Y, Katakai T, Kubo M, Saito T.
CRTAM determines the CD4+ cytotoxic T lymphocyte lineage.
J Exp Med. 213:123-138 (2016)

Ushioda R, Miyamoto A, Inoue M, Watanabe S, Okumura M, Maegawa K, Uegaki K, Fujii S, Fukuda Y, Umitsu M, Takagi J, Inaba K, Mikoshiba K, Nagata K.
Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by ERdj5.
Proc Natl Acad Sci USA. 113:E6055-E6063 (2016)

Jung Y, Riven I, Feigelson SW, Kartvelishvily E, Tohya K, Miyasaka M, Alon R, Haran G.
Three-dimensional localization of T-cell receptors in relation to microvilli using a combination of super-resolution microscopies.
Proc Natl Acad Sci USA. 113(40):E5916-E5924 (2016)
[Highlighted Commentary]

Iftakhar-E-Khuda I, Fair-Mäkelä R, Kukkonen-Macchi A, Elima K, Karikoski M, Rantakari P, Miyasaka M, Salmi M, Jalkanen S.
Gene expression profiling of different arms of lymphatic vasculature identifies new candidates for manipulation of cell traffic.
Proc Natl Acad Sci USA. 113(38):10643-10648 (2016)

Shinoda K, Hirahara K, Iinuma T, Ichikawa T, Suzuki AS, Sugaya K, Tumes DJ, Yamamoto H, Hara T, Tani-ichi S, Ikuta K, Okamoto Y, Nakayama T.
Thy-1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation.
Proc Natl Acad Sci USA. 113(20): E2842-2851 (2016)

Uematsu K, Okumura F, Tonogai S, Joo-Okumura A, Alemayehu DH, Nishikimi A, Fukui Y, Nakatsukasa K, Kamura T.
ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation.
J Cell Biol. 215:95-106 (2016)

Mihara E, Hirai H, Yamamoto H, Tamura-Kawakami K, Matano M, Kikuchi A, Sato T, Takagi J.
Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/a-albumin.
eLife. 5:e11621 (2016)

Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E.
Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility.
eLife. 5:e10561 (2016)

Shirota H, Klinman DM, Ito S, Ito H, Kubo M, Ishioka C.
IL4 from T follicular helper cells downregulates antitumor immunity.
Cancer Immunol Res. 5:61-71 (2016)

Matsunaga Y, Bashiruddin NK, Kitago Y, Takagi J, Suga H.
Allosteric inhibition of a semaphorin 4D receptor plexin B1 by a high-affinity macrocyclic peptide.
Cell Chem Biol. 23:1341-1350 (2016)

Takeda A, Hossain MS, Rantakari P, Simmons S, Sasaki N, Salmi M, Jalkanen S, Miyasaka M.
Thymocytes in Lyve1-CRE/S1pr1^f/f mice accumulate in the thymus due to cell-intrinsic loss of sphingosine-1-phosphate receptor expression.
Front Immunol. 7:489 (2016)

Kobayashi Y, Watanabe T.
Gel-trapped lymphorganogenic chemokines trigger artificial tertiary lymphoid organs and mount adaptive immune responses in vivo.
Front Immunol. 7:316 (2016)

Umitsu M, Sakai K, Ogasawara S, Kaneko M, Asaki R, Tamura-Kawakami K, Kato Y, Matsumoto K, Takagi J.
Probing conformational and functional states of human hepatocyte growth factor by a panel of monoclonal antibodies.
Sci Rep. 9:33149 (2016)

Tanigawa H, Miyata K, Tian Z, Aoi J, Kadomatsu T, Fukushima S, Ogata A, Takeda N, Zhao J, Zhu S, Terada K, Endo M, Morinaga J, Sugizaki T, Sato M, Morioka MS, Manabe I, Mashimo Y, Hata A, Taketomi Y, Yamamoto K, Murakami M, Araki K, Jinnin M, Ihn H, Oike Y.
Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis.
Sci Rep. 6: 34690 (2016)

Liu Z, Man SM, Zhu Q, Vogel P, Frase S, Fukui Y, Kanneganti TD.
DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection.
Sci Rep. 6:27814 (2016)

Morita J, Kano K, Kato K, Takita H, Skagami H, Yamamoto Y, Mihara E, Ueda H, Sato T, Tokuyama H, Arai H, Asou H, Takagi J, Ishitani R, Nishimasu H, Nureki O, Aoki J.
Structural and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase.
Sci Rep. 6:20995 (2016)

Veres TZ, Kopcsányi T, van Panhuys N, Gerner MY, Liu Z, Rantakari P, Dunkel J, Miyasaka M, Salmi M, Jalkanen S, Germain RN.
Allergen-induced CD4+ T-cell cytokine production within airway mucosal DC-T-cell clusters drives the local recruitment of myeloid effector cells.
J Immunol. 198:895-907 (2016)

Huang Y, Getahun A, Heiser RA, Detanico TO, Kirchenbaum GA, Casper TL, Huang C, Aydintug MK, Carding SR, Ikuta K, Huang H, Wysocki LJ, Cambier JC, O’Brien RL, Born WK.
γδ T cells shape pre-immune peripheral B cell populations.
J Immunol. 196:217-231 (2016)

Parmentier R, Zhao Y, Perier M, Akaoka H, Lintunen M, Hou Y, Panula P, Watanabe T, Franco P, Lin JS.
Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model.
Neuropharmacology. 106:20-34 (2016)

Fujii Y, Matsunaga Y, Arimori T, Kitago Y, Ogasawara S, Kaneko M, Kato Y, Takagi J.
Tailored placement of a turn-forming PA tag into the structured domain of a protein to probe its conformational state.
J Cell Sci. 129:1512-1522 (2016)

Okumura F, Uematsu K, Byrne SD, Hirano M, Joo-Okumura A, Nishikimi A, Shuin T, Fukui Y, Nakatsukasa K, Kamura T.
Parallel Regulation of von Hippel-Lindau Disease by pVHL-Mediated Degradation of B-Myb and Hypoxia-Inducible Factor α.
Mol Cell Biol. 36:1803-1817 (2016)

Yugami M, Odagiri H, Endo M, Tsutsuki H, Fujii S, Kadomatsu T, Masuda T, Miyata K, Terada K, Tanoue H, Ito H, Morinaga J, Horiguchi H, Sugizaki T, Akaike T, Gotoh T, Takai T, Sawa T, Mizuta H, Oike Y.
Mice deficient in Angptl2 show increased susceptibility to bacterial infection due to attenuated macrophage activity.
J Biol Chem. 291:18843-18852 (2016)

Baik S, Sekai M, Hamazaki Y, Jenkinson WE, Anderson G.
Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK+ medullary epithelial progenitors.
Eur J Immunol. 46:857-862 (2016)

Mayer CE, Žuklys S, Zhanybekova S, Ohigashi I, Teh HY, Sansom SN, Shikama-Dorn N, Hafen K, Macaulay IC, Deadman ME, Ponting CP, Takahama Y, Holländer GA.
Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla.
Eur J Immunol. 46:846-856 (2016)

Kobayashi S, Watanabe T, Suzuki R, Furu M, Ito H, Ito J, Matsuda S, Yoshitomi H.
TGF-β induces the differentiation of human CXCL13-producing CD4+ T cells.
Eur J Immunol. 46:360-371 (2016)

Suzuki K, Tsunoda H, Omiya R, Matoba K, Baba T, Suzuki S, Segawa H, Kumanogoh A, Iwasaki K, Hattori K, Takagi J.
Structure of the plexin ectodomain bound by semaphorin-mimicking antibodies.
PLoS One. 11:e0156719 (2016)

Tsurusaki S, Tahara-Hanaoka S, Miyake S, Shibagaki S, Imai M, Shibayama S, Kubo M, Shibuya A.
Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis.
Int Immunol. 28:605-609 (2016)

Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, Ishii S, Bando K, Abe T, Kano K, Aoki J, Hayasaka H, Miyasaka M.
Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes.
Int Immunol. 28:283-292 (2016)
[Highlighted In This Issue]

Kitago Y, Kaneko MK, Ogasawara S, Kato Y, Takagi J.
Structural basis for multi-specific peptide recognition by the anti-IDH1/2 monoclonal antibody, MsMab-1.
Biochem Biophys Res Commun. 478:1274-1279 (2016)

Igase M, Hwang CC, Kambayashi S, Kubo M, Coffey M, Miyama TS, Baba K, Okuda M, Noguchi S, Mizuno T.
Oncolytic reovirus synergizes with chemotherapeutic agents to promote cell death in canine mammary gland tumor.
Can J Vet Res. 80(1):21-31 (2016)

Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, Yanagita M.
Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.
JCI Insight. 1:e87680 (2016)