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Takada K, Van Laethem F, Xing Y, Akane K, Suzuki H, Murata S, Tanaka K, Jameson SC, Singer A, Takahama Y.
TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8+ T cells.
Nat Immunol. 16(10):1069-1076 (2015)

Rantakari P, Auvinen K, Jäppinen N, Kapraali M, Valtonen J, Karikoski M, Gerke H, Iftakhar-E-Khuda I, Keuschnigg J, Umemoto E, Tohya K, Miyasaka M, Elima K, Jalkanen S, Salmi M.
The endothelial protein Plvap in lymphatics controls the entry of lymphocytes and antigens into lymph nodes.
Nat Immunol. 16(4):386-396 (2015)


Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, McKenzie AN, Takahashi T, Karasuyama H, Okumura K, Azuma M, Moro K, Akdis CA, Galli SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S.
An interleukin-33-mast cell-interleukin-2 axis suppresses papain-induced allergic airway inflammation by promoting regulatory T cell numbers.
Immunity. 43(1):175–186 (2015)

Adachi T, Kobayashi T, Sugihara E, Yamada T, Ikuta K, Pittaluga S, Saya H, Amagai M, Nagao K.
Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma.
Nat Med. 21:1272-1279 (2015)

Varney ME, Niederkorn M, Konno H, Matsumura T, Gohda J, Yoshida N, Akiyama T, Christie S, Fang J, Miller D, Jerez A, Karsan A, Maciejewski JP, Meetei RA, Inoue J, Starczynowski DT.
Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling.
J Exp Med. 212(11):1967-1985 (2015)

Yamamoto K, Miki Y, Sato M, Taketomi Y, Nishito Y, Taya C, Muramatsu K, Ikeda K, Nakanishi H, Taguchi R7, Kambe N, Kabashima K, Lambeau G, Gelb MH, Murakami M.
The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia.
J Exp Med. 212(11):1901-1919 (2015)

Sawada Y, Honda T, Hanakawa S, Nakamizo S, Murata T, Ueharaguchi-Tanada Y, Ono S, Amano W, Nakajima S, Egawa G, Tanizaki H, Otsuka A,Kitoh A, Dainichi T, Ogawa N, Kobayashi Y, Yokomizo T, Arita M, Nakamura M, Miyachi Y, Kabashima K.
Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses.
J Exp Med. 212(11):1921-1930 (2015)

Kitago Y, Nagae M, Nakata Z, Yagi-Utsumi M, Takagi-Niidome S, Mihara E, Nogi T, Kato K, Takagi J.
Structural basis for amyloidogenic peptide recognition by sorLA.
Nat Struct Mol Biol. 22(3):199-206 (2015)

Noda S, Suárez-Fariñas M, Ungar B, Kim SJ, de Guzman Strong C, Xu H, Peng X, Estrada YD, Nakajima S, Honda T, Shin JU, Lee H, Krueger JG,Lee KH, Kabashima K, Guttman-Yassky E.
The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization.
J Allergy Clin Immunol. 136(5):1254-1264 (2015)

Amano W, Nakajima S, Kunugi H, Numata Y, Kitoh A, Egawa G, Dainichi T, Honda T, Otsuka A, Kimoto Y, Yamamoto Y, Tanimoto A, Matsushita M,Miyachi Y, Kabashima K.
The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling.
J Allergy Clin Immunol. 136(3):667-677 (2015)

Ishihara S, Nishikimi A, Umemoto E, Miyasaka M, Saegusa M, Katagiri K.
Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis.
Nat Commun. 6:8982 (2015)

Yanagihara T, Sanematsu F, Sato T, Uruno T, Duan X, Tomino T, Harada Y, Watanabe M, Wang Y, Tanaka Y, Nakanishi Y, Suyama M, Fukui Y.
Intronic regulation of Aire expression by Jmid6 for self-tolerance induction in the thymus.
Nat Commun. 6:8820 (2015)

Sasaki K, Takada K, Ohte Y, Kondoh H, Sorimachi H, Tanaka K, Takahama Y, Murata S.
Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells.
Nat Commun. 6:7484 (2015)

Hara-Chikuma M, Satooka H, Miyachi Y, Watanabe T, Verkman AS.
Aquaporin-3 mediated hydrogen peroxide transport required for NF-kB signaling in epidermal keratinocytes and development of psoriasis.
Nat Commun. 6:7454 (2015)

Kinjyo I, Qin J, Tan SY, Wellard CJ, Mrass P, Ritchie W, Doi A, Cavanagh LL, Tomura M, Sakaue-Sawano A, Kanagawa O, Miyawaki A, Hodgkin PD, Weninger W.
Real-time tracking of cell cycle progression during CD8(+) effector and memory T-cell differentiation.
Nat Commun. 6:6301 (2015)

Huang Y, Heiser RA, Detanico TO, Getahun A, Kirchenbaum GA, Aydintug MK, Smith CW, Carding SR, Ikuta K, Huang H, Wysocki LJ, Cambier JC, OfBrien RL, Born WK.
ƒมƒย T cells affect IL-4 production and B cell tolerance.
Proc Natl Acad Sci USA. 112(1):E39-48 (2015)

Ohigashi I, Zuklys S, Sakata M, Mayer CE, Hamazaki Y, Minato N, Hollander GA, Takahama Y.
Adult thymic medullary epithelium is maintained and regenerated by lineage-restricted cells rather than bipotent progenitors.
Cell Rep. 13(7):1432-1443 (2015)

Kharitidi D, Apaja PM, Manteghi S, Suzuki K, Malitskaya E, Roldan A, Gingras MC, Takagi J, Lukacs GL, Pause A.
Interplay of endosomal pH and ligand occupancy in integrin ƒฟ5ƒภ1 ubiquitination, endocytic sorting, and cell migration.
Cell Rep. 13(3):599-609 (2015)

Xu W Domingues, R G, Fonseca-Pereira D, Ferreira M, Ribeiro H, Lopez-Lastra S, Motomura Y, Moreira-Santos L, Bihl F, Braud V, Kee B, Brady H, Coles M C, Vosshenrich C, Kubo M, Di Santo J P, Veiga-Fernandes H.
NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors.
Cell Rep. 10(12)2043–2054 (2015)

Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y, Goto M, Yanobu R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata T, Suzuki H.
The thymic cortical epithelium determines the TCR repertoire of IL-17-producing gdT cells.
EMBO Rep. 16(5)638-653 (2015)

Moro K, Ealey KN, Kabata H, Koyasu S.
Isolation and analysis of group 2 innate lymphoid cells in mice.
Nat Protoc. 10(5):792-806 (2015)

Jung Y, Wen T, Mingler MK, Caldwell JM, Wang YH, Chaplin DD, Lee EH, Jang MH, Woo SY, Seoh JY, Miyasaka M, Rothenberg ME.
IL-1ƒภ in eosinophil-mediated small intestinal homeostasis and IgA production.
Mucosal Immunol. 8(4):930-942 (2015)

Nakano N, Nishiyama C, Yagita H, Hara M, Motomura Y, Kubo M, Okumura K,Ogawa H.
Notch Signaling Enhances FcƒรRI-Mediated Cytokine Production by Mast Cells through Direct and Indirect Mechanisms.
J Immunol. 194(9):4535-4544 (2015)

Abe A, Tani-ichi S, Shitara S, Cui G, Yamada H, Miyachi H, Kitano S, Hara T, Abe R, Yoshikai Y, Ikuta K.
An enhancer of the IL-7 receptor ƒฟ-chain locus controls IL-7 receptor expression and maintenance of peripheral T cells.
J Immunol. 195(7):3129-3138 (2015)

Wagatsuma K, Tani-ichi S, Liang B, Shitara S, Ishihara K, Abe M, Miyachi H, Kitano S, Hara T, Nanno M, Ishikawa H, Sakimura K, Nakano M, Kimura H, Ikuta K,.
STAT5 orchestrates local epigenetic changes for chromatin accessibility and rearrangements by direct binding to the TCRƒม locus.
J Immunol. 195(4):1804-1814 (2015)

Tahir S, Fukushima Y, Sakamoto K, Sato K, Fujita H, Inoue J, Uede T, Hamazaki Y, Hattori M, Minato N.
A CD153+CD4+ T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production.
J Immunol. 194(12):5725-5735 (2015)

Kitabatake M, Soma M, Zhang T, Kuwahara K, Fukushima Y, Nojima T, Kitamura D, Sakaguchi N.
JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells.
J Immunol. 194(4):1480-1488 (2015)

Nakamura M, Shibata K, Hatano S, Sato T, Ohkawa Y, Yamada H, Ikuta K, Yoshikai Y.
A genome-wide analysis identifies a Notch-RBP-Jƒศ–IL-7Rƒฟ axis that controls IL-17-producing ƒมƒย T cell homeostasis in mice.
J Immunol. 194(1):243-251 (2015)

Fukazawa T, Hiraiwa N, Umemura T, Mise-Omata S, Obata Y, Doi T.
Egress of Mature Murine Regulatory T Cells from the Thymus Requires RelA.
J Immunol. 194(7):3020-3028 (2015)

Nishijima H, Kitano S, Miyachi H, Morimoto J, Kawano H, Hirota F, Morita R, Mouri Y, Masuda K, Imoto I, Ikuta K, Matsumoto M.
Ectopic Aire expression in the thymic cortex reveals inherent properties of Aire as a tolerogenic factor within the medulla.
J Immunol. 195(10):4641-4649 (2015)

Zhang Z, Zhang W, Huang S, Sun Q, Wang Y, Hu Y, Sun N, Zhang Y, Jiang Z, Minato N, Pin JP, Su L, Liu J.
A GPCR promotes its own surface expression by recruiting a Rap1-dependent signaling cascade.
J Cell Sci. 128(12):2302-2313 (2015)

Sugimoto K, Hayakawa F, Shimada S, Morishita T, Shimada K, Katakai T, Tomita A, Kiyoi H, Naoe T.
Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells.
Sci Rep. 5:13054 (2015)

Shinzawa M, Konno H, Qin J, Akiyama N, Miyauchi M, Ohashi H, Miyamoto-Sato E, Yanagawa H, Akiyama T, Inoue J.
Catalytic subunits of the phosphatase calcineurin interact with NF-ƒศB-inducing kinase (NIK) and attenuate NIK-dependent gene expression.
Sci Rep. 5:10758 (2015)

Doi K, Imai T, Kressler C, Yagita H, Agata Y, Vooijs M, Hamazaki Y, Inoue J, Minato N.
Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia.
Sci Rep. 5:7978 (2015)

Abu-Thuraia A, Gauthier R, Chidiac R, Fukui Y, Screaton RA, Gratton JP, Côté JF.
Axl phosphorylates Elmo scraffold proteins to promote Rac activation and cell invasion.
Mol Cell Biol. 35:76-87 (2015)

Miyatake Y, Sheehy N, Ikeshita S, Hall WW, Kasahara M.
Anchorage-dependent multicellular aggregate formation induces CD44 high cancer stem cell-like ATL cells in an NF-ƒศB- and vimentin-dependent manner.
Cancer Lett. 357(1):355-363 (2015)

Alp ÖS, Durlanik S, Schulz D, McGrath M, Grün JR, Bardua M, Ikuta K, Sgouroudis E, Riedel R, Zehentmeier S, Hauser AE, Tsuneto M, Melchers F, Tokoyoda K, Chang HD, Thiel A, Radbruch A.
Memory CD8+ T cells colocalize with IL-7+ stromal cells in bone marrow and rest interms of proliferation and transcription.
Eur J Immunol. 45:975-987 (2015)

Hirano K, Negishi N, Yazawa M, Yagita H, Habu S, Hozumi K.
Delta-like 4-mediated Notch signaling is required for early T cell development in a three-dimensional thymic structure.
Eur J Immunol. 45:2252-2262 (2015)

Hirao H, Uchida Y, Kadono K, Tanaka H, Niki T, Yamauchi A, Hata H, Watanabe T, Terajima H, Uemoto S.
The protective function of galectin-9 in liver ischemia and reperfusion injury in mice.
Liver Transplantation. 21:969-981 (2015)

Sano T, Iwashita M, Nagayasu S, Yamashita A, Shinjo T, Hashikata A, Asano T, Kushiyama A, Ishimaru N, Takahama Y, Nishimura F.
Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling.
Obesity. 23(7):1460-1471 (2015)

Yashiro T, Kubo M, Ogawa H, Okumura K, Nishiyama C.
PU.1 suppresses Th2 cytokine expression via silencing of GATA3 transcription in dendritic cells.
PLoS One. 10(9):e0137699 (2015)

Yoshioka K, Oda A, Notsu C, Ohtsuka T, Kawai Y, Suzuki S, Nakamura T, Mabuchi Y, Matsuzaki Y, Goitsuka R.
Loss of the homeodomain transcription factor Prep1 perturbs adult hematopoiesis in the bone marrow.
PLoS One. 10(8)e0136107 (2015)

Supper E, Tahir S, Imai T, Inoue J, Minato N.
Modification of Gene Expression, Proliferation, and Function of OP9 Stroma Cells by Bcr-Abl-Expressing Leukemia Cells.
PLoS One. 10(7):e0134026 (2015)

Tateishi R, Akiyama N, Miyauchi M, Yoshinaga R, Sasanuma H, Kudo T, Shimbo M, Shinohara M, Obata K, Inoue JI, Shirakawa M, Shiba D, Asahara H, Yoshida N, Takahashi S, Morita H, Akiyama T.
Hypergravity Provokes a Temporary Reduction in CD4+CD8+ Thymocyte Number and a Persistent Decrease in Medullary Thymic Epithelial Cell Frequency in Mice.
PLoS One. 10(10):e0141650 (2015)

Mohamed R H, Sutoh Y, Itoh Y, Miyatake Y, Otsuka N, Ogasawara K, Kasahara M.
The SKINT1-like gene is inactivated in hominoids but not in all primate species: implications for the origin of epidermal dendritic T cells.
PLoS One. 10(4):e0123258 (2015)

Hayasaka H, Kobayashi D, Yoshimura H, Nakayama EE, Shioda T, Miyasaka M.
The HIV-1 gp120/CXCR4 axis promotes CCR7 ligand-dependent CD4 T cell migration: CCR7 homo- and CCR7/CXCR4 hetero-oligomer formation as a possible mechanism for up-regulation of functional CCR7.
PLoS One. 10(2):e0117454 (2015)

Seino K, Wada H, Baghdadi M.
New immunosuppressive strategies for transplantation based on pluripotent stem cell (PSC)-derived immunoregulatory cells.
Stem Cell Transl Invest. 2:e504 (2015)

Tomaru U, Tsuji T, Kiuchi S, Ishizu A, Suzuki A, Otsuka N, Ito T, Ikeda H, Fukasawa Y, Kasahara M.
Decreased expression of thymus-specific proteasome subunit ƒภ5t in Down syndrome patients.
Histopathology. 67(2):235-244 (2015)

Tashiro Y, Murakami A, Goitsuka R, Shimizu T, Kishimoto H, Azuma T.
An asymmetric antibody repertoire is shaped between plasmablasts and plasma cells after secodary immunization with (4-hydroxy-3-nitrophenyl)acetyl chicken gamma-globulin.
Int Immunol. 27(12):609-620 (2015)

Iinuma C, Waki M, Kawakami A, Yamaguchi M, Tomaru U, Sasaki N, Masuda S, Matsui Y, Iwasaki S, Baba T, Kasahara M, Yoshiki T, Paletta D, Herrmann T, Ishizu A.
Establishment of a vascular endothelial cell-reactive type II NKT cell clone from a rat model of autoimmune vasculitis.
Int Immunol. 27(2):105-114 (2015)

Yasushi H, Yasuyuki T, Akikazu M, Miyuki N, Takeyuki S, Kubo M, Peter D. Burrows,Takachika A.
High Affinity IgM+ Memory B Cells Are Generated through a Germinal Center-Dependent Pathway.
Mol Immunol. 68(2 Pt C):617-627 (2015)

Ugajin T, Nishida K, Yamasaki S, Suzuki J, Mita M, Kubo M, Yokozeki H, Hirano T.
Zinc-binding metallothioneins are key modulators of IL-4 production by basophils.
Mol Immunol. 66(2):180-188 (2015)

Kiuchi S, Ikeshita S, Miyatake Y, Kasahara M.
Pancreatic cancer cells express CD44 variant 9 and multidrug resistance protein 1 during mitosis.
Exp Mol Pathol. 98(1):41-46 (2015)

Nakano Y, Negishi N, Gocho S, Mine T, Sakurai Y, Yazawa M, Abe K, Yagita H, Habu S, Kageyama R, Kawaguchi Y, Hozumi K.
Disappearance of centroacinar cells in the Notch ligand-deficient pancreas.
Genes Cells. 20:500-511 (2015)

Otsuka A, Kabashima K.
Contribution of Basophils to Cutaneous Immune Reactions and Th2-Mediated Allergic Responses.
Front Immunol. 6:393 (2015)

Seki T, Yamamoto M, Taguchi Y, Miyauchi M, Akiyama N, Yamaguchi N, Gohda J, Akiyama T, Inoue J.
Visualization of RelB expression and activation at the single-cell level during dendritic cell maturation in Relb-Venus knock-in mice.
J Biochem. 158(6):485-495 (2015)

Noma N, Asagiri M, Takeiri M, Ohmae S, Takemoto K, Iwaisako K, Minato N, Maeda-Yamamoto M, Simizu S, Umezawa K.
Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-ƒศB Inhibitor DHMEQ in Mast Cells.
Int Arch Allergy Immunol. 166(2):84-90 (2015)

Fujita H, Hatanaka Y, Sutoh Y, Suzuki Y, Oba K, Hatanaka KC, Mitsuhashi T, Otsuka N, Fugo K, Kasahara M, Matsuno Y.
Immunohistochemical Validation and Expression Profiling of NKG2D Ligands in a Wide Spectrum of Human Epithelial Neoplasms.
J Histochem Cytochem. 63(3):217-227 (2015)

Matsushita H, Hosoi A, Ueha S, Abe J, Fujieda N, Tomura M, Maekawa R, Matsushima K, Ohara O, Kakimi K.
Cytotoxic T lymphocytes block tumor growth both by lytic activity and IFN-ƒม-dependent cell cycle arrest.
Cancer Immunol Res. 3:26-36 (2015)

Takatori H, Kawashima H, Matsuki A, Yamagata M, Iwamoto T, Sanayama Y, Nishikawa N, Ikeda K, Kagami S, Kubo M, Hori S, Nakajima H.
Helios enhances Treg function in cooperation with Foxp3.
Arthritis Rheumatol. 67(6):1491-1502 (2015)