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Omatsu Y, Seike M, Sugiyama T, Kume T, Nagasawa T.
Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation.
Nature. 508:536-540(2014)

Venkatesh B, Lee AP, Ravi V, Maurya AK, Lian MM, Swann JB, Ohta Y, Flajnik MF, Sutoh Y, Kasahara M, Hoon S, Gangu V, Roy SW, Irimia M, Korzh V, Kondrychyn I, Lim ZW, Tay BH, Tohari S, Kong KW, Ho S, Lorente-Galdos B, Quilez J, Marques-Bonet T, Raney BJ, Ingham PW, Tay A, Hillier LW, Minx P, Boehm T, Wilson RK, Brenner S, Warren WC.
Elephant shark genome provides unique insights into gnathostome evolution.
Nature. 505:174-179 (2014)

Sreeramkumar V, Adrover JM, Ballesteros I, Cuartero MI, Rossaint J, Bilbao I, Nácher M, Pitaval C, Radovanovic I, Fukui Y, McEver RP, Filippi M-D, Lizasoain I, Ruiz-Cabello J, Zarbock A, Moro MA, Hidalgo A.
Neutrophils scan for activated platelets to initiate inflammation.
Science 346:1234-1238(2014)

Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone JA, Takayanagi H.
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
Nat Med. 20:62-68 (2014)

Sekai M, Hamazaki Y, Minato N.
Medullary thymic epithelial stem cells maintain a functional thymus to ensure lifelong central T cell tolerance.
Immunity. 41:753-761 (2014)

Moalli F, Cupovic J, Thelen F, Halbherr P, Fukui Y, Narumiya S, Ludewig B, Stein JV.
Thromboxane A2 acts as tonic immunoregulator by preferentialdisruption of low-avidity CD4+ T cell-dendritic cell interactions.
J Exp Med.211:2507-2517(2014)

Ogawa K, Tanaka Y, Uruno T, Duan X, Harada Y, Sanematsu F, Yamamura K, Terasawa M, Nishikimi A, Côté J-F, Fukui Y.
DOCK5 functions as a key signaling adaptor that links FcƒรRI signals to microtubule dynamics during mast cell degranulation
J Exp Med. 211:1407-1419 (2014)

Mizuno R, Kamioka Y, Kabashima K, Imajo M, Sumiyama K, Nakasho E, Ito T, Hamazaki Y, Okuchi Y, Sakai Y, Kiyokawa E, Matsuda M.
In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines.
J Exp Med. 211:1123-1136 (2014)

Caglayan S, Takagi-Niidome S, Liao F, Carlo A-S, Schmidt V, Burgert T, Kitago Y, Füchtbauer E-M, Füchtbauer A, Holtzman DM, Takagi J, Wilnow TE.
Lysosomal Sorting of Amyloid-.FNb by the SORLA Receptor Is Impaired by a Familial Alzheimer's Disease Mutation.
Sci Transl Med. 6:223ra20 (2014)

Totsuka N, Kim Y-G, Kanemaru K, Niizuma K, Umemoto E, Nagai K, Tahara-Hanaoka S, Nakahashi-Oda C, Honda S, Miyasaka M, Shibuya K, Shibuya A.
Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration.
Nat Commun. 5:4710 (2014)

Masahata K, Umemoto E, Kayama H, Kotani M, Nakamura S, Kurakawa T, Kikuta J, Gotoh K, Motooka D, Sato S, Higuchi T, Baba Y, Kurosaki T, Kinoshita M, Shimada Y, Kimura T, Okumura R, Takeda A, Tajima M, Yoshie O, Fukuzawa M, Kiyono H, Fagarasan S, Iida T, Ishii M, Takeda K.
Generation of colonic IgA-secreting cells in the caecal patch.
Nat Commun. 5:3704 (2014)

Wu L, Parekh V V, Hsiao J, Kitamura D, Van Kaer L.
Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance.
Proc Natl Acad Sci USA. 111 (43): E4638-4647 (2014)

Shand FH, Ueha S, Otsuji M, Koid SS, Shichino S, Tsukui T, Kosugi-Kanaya M, Abe J, Tomura M, Ziogas J, Matsushima K.
Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes.
Proc Natl Acad Sci USA. 111:7771-7776 (2014)

Kimura T, Nagao Y, Hashimoto H, Yamamoto-Shhiraishi Y, Yamamoto S, Yabe T, Takada S, Kinoshita M, Kuroiwa A, Naruse K.
Leucophores are similar to xanthophores in their specificatio and differentiation processes in medaka
Proc Natl Acad Sci USA. 111:7343-7348 (2014)

Cui G, Hara T, Simmons S, Wagatsuma K, Abe A, Miyachi H, Kitano S, Ishii M, Tani-ichi S, Ikuta K.
Characterization of the interleukin-15 niche in primary and secondary lymphoid organs in vivo.
Proc Natl Acad Sci USA. 111:1915-1920 (2014)

Nishikimi A, Ishihara S, Ozawa M, Etoh K, Fukuda M, Kinashi T, Katagiri K.
Rab13 acts downstream of the kinase Mst1 to activate the integrin LFA-1 for lymphocyte trafficking.
Sci Signal. 7(336):ra72 (2014)

Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song SY, Hoshino T, Yagita H, Ohteki T, Iwata M.
Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells.
Mucosal Immunol. 7: 786-801 (2014)

Wen Y, Elliott MJ, Huang Y, Miller TO, Corbin DR, Hussain L-R, Ratajczak MZ, Fukui Y, Ildstad ST.
DOCK2 is critical for CD8+TCR- graft facilitating cells to enhance engraftment of hematopoietic stem and progenitor cells.
Stem Cells. 32:2732-2743 (2014)

Nakamizo S, Egawa G, Tomura M, Sakai S, Tsuchiya S, Kitoh A, Honda T, Otsuka A, Nakajima S, Dainichi T, Tanizaki H, Mitsuyama M, Sugimoto Y, Kawai K, Yoshikai Y, Miyachi Y, Kabashima K.
Dermal Vƒม4+ ƒมƒย T Cells Possess a Migratory Potency to the Draining Lymph Nodes and Modulate CD8+ T-Cell Activity through TNF-ƒฟ Production.
J Invest Dermatol.[Epub ahead of print] Dec 10(2014)

Ibusuki A, Kawai K, Yoshida S, Uchida Y, Nitahara-Takeuchi A, Kuroki K, Kajikawa M, Ose T, Maenaka K, Kasahara M, Kanekura T.
NKG2D triggers cytotoxicity in murine epidermal ƒมƒย T cells via PI3K-dependent, Syk/ZAP70-independent signaling pathway.
J Invest Dermatol. 134:396-404 (2014)

Hizukuri Y, Oda T, Tabata S, Tamura-Kawakami K, Oi R, Sato M, Takagi J, Akiyama Y, Nogi T.
A structure-based model of substrate discrimination by a non-canonical PDZ tandem in the intramembrane-cleaving protease RseP.
Structure. 22:326-336 (2014)

Damoulakis G, Gambardella L, Rossman K, Lawson C, Anderson K, Fukui Y, Welch H, Der C, Stephens L, Hawkins P.
P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.
J Cell Sci. 127:2589-2600 (2014)

Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F, Nishikimi A, Côté JF, Sumimoto H, Fukui Y.
DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation.
J Immunol. 193:5660-5667(2014)

Abe J, Shichino S, Ueha S, Hashimoto S, Tomura M, Inagaki Y, Stein JV, Matsushima K.
Lymph Node Stromal Cells Negatively Regulate Antigen-Specific CD4+ T Cell Responses.
J Immunol. 193:1636-44 (2014)

Fukao S, Haniuda K, Nojima T, Takai T, Kitamura D.
Gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells.
J Immunol. 193:635-644(2014)

Tan J, Watanabe T.
Murine Spleen Tissue Regeneration from Neonatal Spleen Capsule Requires Lymphotoxine Priming of Stromal Cells.
J Immunol. 193:1194-1203 (2014)

Katakai T, Kondo N, Ueda Y, Kinashi T.
Autotaxin produced by stromal cells promotes LFA-1–ndependent and Rhp-dependent interstitial T cell motility in the lymph node paracortex.
J Immunol. 193F617|626 (2014)

Kono A, Brameier M, Roos C, Suzuki S, Shigenari A, Kametani Y, Kitaura K, Suzuki R, Inoko H, Walter L, Shiina T.
Genomic sequence analysis of the major histocompatibility complex (MHC) class I G/F segment in common marmoset (Callithrix jacchus).
J Immunol. 192:3239-3246 (2014)

Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.
CD28-CD80/86 and CD40-CD40L costimulatory pathways cooperate for development of thymic medullary epithelium and thymocyte self tolerance.
J Immunol. 192:630-640 (2014)

Tomura M, Hata A, Matsuoka S, Shand FH, Nakanishi Y, Ikebuchi R, Ueha S, Tsutsui H, Inaba K, Matsushima K, Miyawaki A, Kabashima K, Watanabe T, Kanagawa O.
Tracking and quantification of dendritic cell migration and antigen trafficking between the skin and lymph nodes.
Sci Rep. 4:6030 (2014)

Shiheido H, Aoyama T, Takahashi H, Hanaoka K, Abe T, Nishida E, Chen C, Koga O, Hikida M, Shibagaki Y, Morita A, Nikawa T, Hattori S, Watanabe T, Shimizu J.
A novel CD3-specific antibody induces immunosuppression via impaired phosphorylation of LAT and PLCƒม1 following T-cell stimulation.
Eur J Immunol. 44:1770-1780 (2014)

Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, Ishimaru N, Takada K, Butcher GW, Takahama Y.
Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.
Eur J Immunol. 44:561-572 (2014)

Bhingare AC, Ohno T, Tomura M, Zhang C, Aramaki O, Otsuki M, Tagami J, Azuma M.
Dental pulp dendritic cells migrate to regional lymph nodes.
J Dent Res. 93:288-293(2014)

Miyabe Y, Miyabe C, Iwai Y, Yokoyama W, Sekine C, Sugimoto K, Harigai M, Miyasaka M, Miyasaka N, Nanki T.
Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid - lysophosphatidic acid receptor 1 cascade.
Arthritis Res Ther. 16:461(2014)

Okumura K, Saito M, Aoto Y, Hachiya T, Sakakibara Y, Katsuragi Y, Hirose S, Kominami R, Goitsuka R, Nakamura T, Wakabayashi Y.
Meis1 regulates epidermal stem cells and is required for skin tumorigenesis.
PloS One. 9(7):e102111 (2014)

Kudo H, Wada H, Sasaki H, Tsuji H, Otsuka R, Baghdadi M, Kojo S, Chikaraishi T, Seino K.
Induction of Macrophage-Like Immunosuppressive Cells from Mouse ES Cells That Contribute to Prolong Allogeneic Graft Survival.
PLoS One. 9(10):e111826(2014)

Ohoka Y, Yokota-Nakatsuma A, Maeda N, Takeuchi H, Iwata M.
Retinoic Acid and GM-CSF coordinately induce retinal dehydrogenase 2 (RALDH2) expression through cooperation between the RAR/RXR complex and Sp1 in dendritic cells.
PLoS One. 9(5):e96512(2014)

Shiheido H, Chen C, Hikida M, Watanabe T, Shimizu J.
Modulation of the human T cell response by a novel non-mitogenic anti-CD3 antibody.
PLoS One. 9(4):e94324 (2014)

Moutai T, Yamana H, Nojima T, Kitamura D.
A novel and effective cancer immunotherapy mouse model using antigen-specific B cells selected in vitro.
PLoS One. 9(3):e92732 (2014)

Nagatake T, Fujita H, Minato N, Hamazaki Y.
Enteroendocrine cells are specifically marked by cell surface expression of claudin-4 in mouse small intestine.
PLoS One. 9(3):e90638 (2014)

Hirayama T, Asano Y, Iida H, Watanabe T, Nakamura T, Goitsuka R.
Meis1 is required for the maintenance of postnatal thymic epithelial cells.
PLoS One. 9(3):e89885 (2014)

Okada T, Nitta T, Kaji K, Takashima A, Oda H, Tamehiro N, Goto M, Okamura T, Patrick MS, Suzuki H.
Differential Function of Themis CABIT Domains during T Cell Development.
PLoS One. 9(2):e89115 (2014)

Ariki R, Morikawa S, Mabuchi Y, Suzuki S, Nakatake M, Yoshioka K, Hidano S, Nakauchi H, Matsuzaki Y, Nakamura T, Goitsuka R.
Homeodomain transcription factor meis1 is a critical regulator of adult bone marrow hematopoiesis.
PLoS One. 9(2):e87646 (2014)

Kanda R, Sutoh Y, Kasamatsu J, Maenaka K, Kasahara M, Ose T.
Crystal structure of the lamprey variable lymphocyte receptor C reveals an unusual feature in its N-terminal capping module.
PLoS One. 9(1):e85875 (2014)

Ando R, Noda K, Tomaru U, Kamoshita M, Ozawa Y, Notomi S, Hisatomi T, Noda M, Kanda A, Ishibashi T, Kasahara M, Ishida S.
Decreased proteasomal activity causes photoreceptor degeneration in mice.
Invest Ophthalmol Vis Sci. 55(7):4682-4690 (2014)

Mise-Omata S, Alles N, Fukazawa T, Aoki K, Ohya K, Jimi E, Obata Y, Doi T.
NF-ƒศB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation.
Int Immunol. 26(11):607-18 (2014)

Watanabe M, Kudo Y, Kawano M, Nakayama M, Nakamura K, Kameda M, Ebara M, Sato T, Nakamura M, Omine K, Kametani Y, Suzuki R, Ogasawara K.
NKG2D functions as an activating receptor on natural killer cells in common marmoset (callithrix jacchus).
Int Immunol. 26(11):597-606 (2014)

Matsui N, Ohigashi I, Tanaka K, Nakagawa Y, Kondo K, Kitagawa T, Yamashita S, Nomura Y, Takahama Y, Kaji R.
Increased number of Hassall's corpuscles in myasthenia gravis patients carrying thymic hyperplasia.
J Neuroimmunol. 269:56-61 (2014)

Sutoh Y, Kasahara M.
Copy number and sequence variation of leucine-rich repeat modules suggests distinct functional constraints operating on variable lymphocyte receptors expressed by agnathan T cell-like and B cell-like lymphocytes.
Immunogenetics. 66:403-409(2014)

Störbel P, Hartmann E, Rosenwald A, Kalla J, Ott G, Schalke B, Kasahara M, Tomaru U, Marx A.
Corticomedullary differentiation and maturational arrest in thymomas.
Histopathology. 64:557-566 (2014)

Ikeshita S, Miyatake Y, Otsuka N, Kasahara M.
MICA/B expression in macrophage foam cells infiltrating atherosclerotic plaques.
Exp Mol Pathol. 97(1):171-175(2014)

Yamada Y, Tomaru U, Ishizu A, Kiuchi T, Kasahara M, Matsuno Y.
Expression of thymoproteasome subunit ƒภ5t in type AB thymoma.
J Clin Pathol. 67:276-278 (2014)

Togoo K, Takahama Y, Takada K.
Alpha-smooth muscle actin expression identifies subpopulations of lymph node non-hematopoietic cells.
Biochem Biophys Res Commun. 449:241-247 (2014)

Tsuneto M, Kajikhina E, Seiler K, Reimer A, Tornack J, Bouquet C, Simmons S, Knoll M, Wolf I, Tokoyoda K, Hauser A, Hara T, Tani-Ichi S, Ikuta K, Grün J. R, Grützkau A, Engels N, Wienands J, Yanagisawa Y, Ohnishi K , Melchers F.
Environments of B cell development.
Immunol Lett. 157:60-63. (2014).

Nakahara R, Kawai Y, Oda A, Nishimura M, Murakami A, Azuma T, Kaifu T, Goitsuka, R.
Generation of a Tlx1(CreER-Venus) knock-in mouse strain for the study of spleen development.
Genesis. 52(11):916-923 (2014)

Ohshima S, Mori S, Shigenari A, Miyamoto A, Takasu M, Imaeda N, Nunomura S, Okayama Y, Tanaka M, Kitagawa H, Kulski JK, Inoko H, Ando A, Kametani Y.
Differentiation ability of multipotent hematopoietic stem/progenitor cells detected by a porcine specific anti-CD117 monoclonal antibody.
Biosci Trends. 8:308-315 (2014)

Goto Y, Kametani Y, Kikugawa A, Tsuda B, Miyazawa M, Kajiwara H, Terao Y, Takekoshi S, Nakamura N, Takeda S, Mikami M.
Defect of tropomyosin-related kinase B isotype expression in ovarian clear cell adenocarcinoma.
Biosci Trends. 8:93-100 (2014)

Fujii Y, Kaneko M, Neyazaki M, Nogi T, Kato Y, Takagi J.
PA tag: a versatile protein tagging system using a super high affinity antibody against a dodecapeptide derived from human podoplanin.
Protein Expres Purif. 95:240-247 (2014)

Laurin M, Dumouchel A, Fukui Y, Côté J-F.
The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo.
Small GTPases. 4:221-230 (2014)

Shiheido H, Kitagori K, Sasaki C, Kobayashi S, Aoyama T, Urata K, Oku T, Hirayama Y, Yoshitomi H, Hikida M, Yoshifuji H, Mimori T, Watanabe T, Shimizu J.
Human T cells expressing BEND3 on their surface represent a novel subpopulation that preferentially produces IL-6 and IL-8.
Immunity, Inflammation and Disease. 2:35-43 (2014)