原著論文 （２０１２年）

Kanatsu-Shinohara M, Inoue K, Takashima S, Takehashi M, Ogonuki N, Morimoto H, Nagasawa T, Ogura A, Shinohara T.
Reconstitution of mouse spermatogonial stem cell niches in culture.
Cell Stem Cell. 11:567-578 (2012)

Suzuki S, Iwamoto M, Saito Y, Fuchimoto D, Sembon S, Suzuki M, Mikawa S, Hashimoto M, Aoki Y, Najima Y, Takagi S, Suzuki N, Suzuki E, Kubo M, Mimuro J, Kashiwakura Y, Madoiwa S, Sakata Y, Perry AC, Ishikawa F, Onishi A.
Il2rg gene-targeted severe combined immunodeficiency pigs.
Cell Stem Cell. 10:753-758 (2012)

Roberts NM, White AJ, Jenkinson WE, Turchinovich G, Nakamura K, Withers DR, McConnell FM, Desanti GE, Benezech C, Parnell SM, Cunningham AF,Paolino M, Penninger J, Simon K, Nitta T, Ohigashi I, Takahama Y, Caamano JH, Hayday AC, Lane PJ, Jenkinson EJ, Anderson G.
Rank signaling links the development of invariant γδ T cell progenitors and Aire+ medullary epithelium.
Immunity. 36:427-437 (2012)

Nishiyama C, Uesaka T, Manabe T, Yonekura Y, Nagasawa T, Newgreen DF, Young HM, Enomoto H.
Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system.
Nat Neurosci. 15:1211-1218 (2012)

Nakajima S, Igyártó BZ, Honda T, Egawa G, Otsuka A, Hara-Chikuma M, Watanabe N, Ziegler SF, Tomura M, Inaba K, Miyachi Y, Kaplan DH, Kabashima K.
Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling.
J Allergy Clin Immunol. 129:1048-1055.e6 (2012)

Nagae M, Re S, Mihara E, Nogi T, Sugita Y, Takagi J.
Crystal structure of a5b1 integrin ectodomain: Atomic details of the fibronectin receptor.
J Cell Biol. 197:131-140 (2012)

Sasaki I, Hoshino K, Sugiyama T, Yamazaki C, Yano T, Iizuka A, Hemmi H, Tanaka T, Saito M, Sugiyama M, Fukuda Y, Ohta T, Sato K, Ainai A, Suzuki T, Hasegawa H, Toyama-Sorimachi N, Kohara H, Nagasawa T, Kaisho T.
Spi-B is critical for plasmacytoid dendritic cell function and development.
Blood. 120:4733-4743 (2012)

Nakamura-Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T, Nagasawa T, Suda T, Kubota Y.
Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration.
Blood. 119:5429-5437 (2012)

Harada Y, Tanaka Y, Terasawa M, Pieczyk M, Habiro K, Katakai T, Hanawa-Suetsugu K, Kukimoto-Niino M, Nishizaki T, Shirouzu M, Duan X, Uruno T, Nishikimi A, Sanematsu F, Yokoyama S, Stein jV, Kinashi T, Fukui Y.
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.
Blood. 119:4451-4461 (2012)

Takagi S, Saito Y, Hijikata A, Tanaka S, Watanabe T, Hasegawa T, Mochizuki S, Kunisawa J, Kiyono H, Koseki H, Ohara O, Saito T, Taniguchi S, Shultz LD, Ishikawa F.
Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.
Blood. 119:2768-2777 (2012)

Kato K, Nishimasu H, Okudaira S, Mihara E, Ishitani R, Takagi J , Aoki J, Nureki O.
Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
Proc Natl Acad Sci USA. 109:16876-16881 (2012)

Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S.
Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 andf its partner ELMO1 from their autoinhibited forms.
Proc Natl Acad Sci USA. 109:3305-3310 (2012)

Nakagawa Y, Ohigashi I, Nitta T, Sakata M, Tanaka K, Murata S, Kanagawa O, Takahama Y.
Thymic nurse cells provide microenvironment for secondary TCRα rearrangement in cortical thymocytes.
Proc Natl Acad Sci USA. 109:20572-20577 (2012)

Ueda Y, Katagiri K, Tomiyama T, Yasuda K, Habiro K, Katakai T, Ikehara S, Matsumoto M, Kinashi T.
Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus.
Nat Commun. 3:1098 (2012)

Mashimo T, Takizawa A, Kobayashi J, Kunihiro Y, Yoshimi K, Ishida S, Tanabe K, Yanagi A, Tachibana A, Hirose J, Yomoda J, Morimoto S, Kuramoto T, Voigt B, Watanabe T, Hiai H, Tateno C, Komatsu K, Serikawa T.
Generation and Characterization of Severe Combined Immunodeficiency Rats.
Cell Reports 2:685-694 (2012)

Tanaka H, Miyazaki N, Matoba K, Nogi T, Iwasaki K, Takagi J.
Higher-order architecture of cell adhesion mediated by polymorphic synaptic adhesion molecules neurexin and neuroligin.
Cell Reports. 2:101-110 (2012)

Hayashi I, Takatori S, Urano Y, Takagi J, Sakata-Yanagimoto M, Iwanari, H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T.
Neutralization of the g-secretase activity by monoclonal antibody against extracellular domain of nicastrin.
Oncogene. 31:787-798 (2012)

McKee KK, Yang DH, Patel R, Chen ZL, Strickland S, Takagi J, Sekiguchi K, Yurchenco PD.
Schwann Cell Myelination Requires Integration of Laminin Activities.
J Cell Sci. 125:4609-4619 (2012)

Chen Q, Takada R, Takada S.
Loss of Porcupine impairs convergent extension during gastrulation in zebrafish.
J Cell Sci. 125(Pt 9):2224-2234 (2012)

Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saito N, Sakaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H, Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, Fukui Y.
Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.
Chem Biol. 19:488-497 (2012)

Zuklys S, Mayer CE, Zhanybekova S, Stefanski H, Nusspaumer G, Gill J, Barthlott T, Chappaz S, Nitta T, Dooley J, Nogales-Caballero R, Takahama Y, Finke D, Liston A, Blazar BR, Pascual-Montano A, Hollander GA.
miRNAs control the maintenance of thymic epithelia and their competence for T lineage committment and thymocyte selection.
J Immunol. 189:3894-3904 (2012)

Sudo T, Yokota T, Oritani K, Satoh Y, Sugiyama T, Ishida T, Shibayama H, Ezoe S, Fujita N, Tanaka H, Maeda T, Nagasawa T, Kanakura Y.
The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal.
J Immunol. 189:200-210 (2012)

*Umemoto E, *Otani K, Ikeno T, Verjan Garcia N, Hayasaka H, Bai Z, Jang MH, Tanaka T, Nagasawa T, Ueda K, Miyasaka M. (*equal contribution)
Constitutive plasmacytoid dendritic cell migration to the splenic white pulp is cooperatively regulated by CCR7- and CXCR4-mediated signaling.
J Immunol. 189:191-199 (2012)

Tanaka S, Saito Y, Kunisawa J, Kurashima Y, Wake T, Suzuki N, Shultz LD, Kiyono H, Ishikawa F.
Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice.
J Immunol. 188:6145-6155 (2012)

Sakamoto S, Wakae K, Anzai Y, Murai K, Tamaki N, Miyazaki M, Miyazaki K, Romanow WJ, Ikawa T, Kitamura D, Yanagihara I, Minato N, Murre C, Agata Y.
E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulinκlocus.
J Immunol. 188:5547-5560 (2012)

Fujimori S, Hirai N, Ohashi H, Masuoka K, Nishikimi A, Fukui Y, Washio T, Oshikubo T, Yamashita T, Miyamoto-Sato E.
Next-generation sequencing coupled with a cell-free display technology for high-throughput production of reliable interactome data.
Scientific Reports 2:1-5 (2012)

Yoshino M, Okuyama K, Murata A, Tomura M, Hayashi S.
CCR7-independent transport of skin antigens occurs in the dermis.
Eur J Immunol. 42:1459-1467 (2012)

Ishimaru N, Yamada A, Nitta T, Arakaki R, Lipp M, Takahama Y, Hayashi Y.
CCR7 with S1P1 signaling through AP1 for migration of Foxp3+ regulatory T cells controls autoimmune exocrinopathy.
Am J Pathol. 180:199-208 (2012)

Chtanova T., Hampton HR, Waterhouse LA, Wood K, Tomura M, Miwa Y, Mackay RC, Brink R, Phan TG. Real-time interactive two-photon photoconversion of recirculating lymphocytes for discontinuous cell tracking in live adult mice.
J Biophotonics. 5: [Epub ahead of print] (2012)

Terasawa M, Uruno T, Mori S, Kukimoto-Niino M, Nishikimi A, Sanematsu F, Tanaka Y, Yokoyama S, Fukui Y.
Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration.
PLoS One 7:e46277 (2012)

Fujita H, Hamazaki Y, Noda Y, Oshima M, ,Minato N.
Claudin-4 deficiency results in urothelial hyperplasia and lethal hydronephrosis.
PLoS One. 7:e52272 (2012)

Chiu CH, Chou CW, Takada S, Liu YW.
Development and fibronectin signaling requirements of the zebrafish interrenal vessel.
PLoS One. 7(8):e43040 (2012)

Murata K, Kitaori T, Oishi S, Watanabe N, Yoshitomi H, Tanida S, Ishikawa M, Kasahara T, Shibuya H, Fujii N, Nagasawa T, Nakamura T, Ito H.
Stromal cell-derived factor 1 regulates the actin organization of chondrocytes and chondrocyte hypertrophy.
PLoS One. 7(5):e37163 (2012)

Yabe T, Takada S.
Mesogenin causes embryonic mesoderm progenitors to differentiate during development of zebrafish tail somites.
Dev Biol. 370:213-222 (2012)

Hirata T, Nomachi A, Tohya T, Miyasaka M, Tsukita S, Watanabe T, Narumiya S.
Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis.
Int Immunol. 24:705-717 (2012)

Abe J, Ueha S, Yoneyama H, Shono Y, Kurachi M, Goto A, Fukayama M, Tomura M, Kakimi K, Matsushima K.
B cells regulate antibody responses through the medullary remodeling of inflamed lymph nodes.
Int Immunol. 24:17-27 (2012)

Sugie T, Murata-Hirai K, Iwasaki M, Morita CT, Li W, Okamura H, Minato N, Toi M, Tanaka Y.
Zoledronic acid-induced expansion of γδT cells from early-stage breast cancer patients: effect of IL-18 on helper NK cells.
Cancer Immunol Immunoth. Nov 15 [Epub ahead of print] (2012)

Tsuchiya A, Imai M, Kamimura H, Takamura M, Yamagiwa S, Sugiyama T, Nomoto M, Heike T, Nagasawa T, Nakahata T, Aoyagi Y.
Increased Susceptibility to Severe Chronic Liver Damage in CXCR4 Conditional Knock-Out Mice.
Dig Dis Sci. 57:2892-2900 (2012)

Matoba K, Takagi J, Yasunaga T, Jinnai H, Iwasaki K.
Tilt-angle measurement of a sample stage using a capacitive liquid-based inclinometer.
J Electron Microsc (Tokyo). 61(3):193-198 (2012)

Kato K, Nishimasu H, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O.
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp1.
Acta Crystallogr F. 68(7):778-782 (2012)