Okazaki Lab

Jul 2, 2019
Okamura H, Okazaki IM, Shimizu K, Maruhashi T, Sugiura D, Mizuno R, Okazaki T.
PD-1 aborts the activation trajectory of autoreactive CD8 T cells to prohibit their acquisition of effector functions.
J Autoimmunity, Epub ahead of print
Journal site

Jul, 2019
Sugiura D et al. Science, 364:558 (2019) was highlighted by Cancer Discovery.

Journal site

May 20, 2019
Sugiura D et al. Science, 364:558 (2019) was highlighted by Nature Immunology.

Journal site

May 8, 2019
Sugiura D et al. Science, 364:558 (2019) was highlighted by ACIR.

Journal site

Apr 18, 2019
Sugiura D, Maruhashi T, Okazaki IM, Shimizu K, Maeda TK, Takemoto T, and Okazaki T.
Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses.
Science, First Release (Apr18, 2019)
Journal site

Apr, 2018
Natsumi Maeda received the Katsunuma Scholarship.

Mar 29, 2019
Mizuno R, Sugiura D, Shimizu K, Maruhashi T, Watada M, Okazaki IM, and Okazaki T.
PD-1 primarily targets TCR signal in the inhibition of functional T cell activation.
Frontiers in Immunology, 10:630, 2019
Journal site

Mar 6, 2019
Maeda TK et al., J Biol Chem, 294(15): 6017-6026 was highlighted by ACIR
Journal site

Feb, 2019
Two medical students (Jun Ikubo and Taisuke Yamamoto) have joined our laboratory.

Feb 13, 2019
Maeda TK, Sugiura D, Okazaki IM, Maruhashi T, and Okazaki T.
Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation.
Journal of Biological Chemistry, 294(15): 6017-6026
PubMed

Feb 13, 2019
Mizuno R, Maruhashi T, Sugiura D, Shimizu K, Watada M, Okazaki IM, and Okazaki T.
PD-1 efficiently inhibits T cell activation even in the presence of co-stimulation through CD27 and GITR.
Biochemical and Biophysical Research Communications, 511(3):491-497, 2019
PubMed

Jan, 2019
Takumi Maruhashi was awarded the Oka Prize.

Nov 16, 2018
News & Views on Maruhashi et al. (Nature Immunology, 19:1415-1426, 2018） by Drs. Lui and Davis. "LAG-3: a very singular immune checkpoint"
Journal site

Oct 22, 2019
Maruhashi T, Okazaki IM, Sugiura D, Takahashi S, Maeda TK, Shimizu K, and Okazaki T.
LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII.
Nature Immunology, 19:1415-1426, 2018
PubMed

Oct 1, 2018
Dr. Tasuku Honjo, the mentor of Okazaki IM and Okazaki T, has been announced to receive the Nobel Prize in physiology or medicine.

Jun, 2018
A research project "Singularity biology" has been started. This project is supported by the Grant-in-Aid by the Japan Society for the Promotion of Science for Scientific Research on Innovative Areas.
http://singularity-bio.jp/eng/

Jun 30, 2018
Reina Mizuno received the best presentation award in the 17th Shikoku Immunology Forum.

Apr, 2017
Natsumi Maeda received the Katsunuma Scholarship.

Mar, 2018
Ryuki Abiru joined our group.
Two medical students (Riko Okano and Mitsuki Shimizu) have joined our laboratory.

Feb, 2018
Reina Mizuno was awarded the
Kouraku Prize.