Publications from the Division of Experimental Immunology at the University of Tokushima
[2020]
Cowan JE, Takahama Y, Bhandoola A, Ohigashi I
Postnatal involution and counter-involution of the thymus
Front Immunol 11:897 (2020)
Lucas B, White AJ, Cosway EJ, Parnell SM, James KD, Jones ND, Ohigashi I, Takahama Y, Jenkinson WE, Anderson G.
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells
Nat Commun 11:2198 (2020)
Kondo H, Matsumura T, Kaneko M, Inoue K, Kosako T, Ikawa M, Takahama Y, Ohigashi I.
PITHD1 is a proteasome-interacting protein essential for male fertilization
J Biol Chem 295:1658-1672 (2020)
[2019]
Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin AC,Hoffmann V, Kozai M, Matsushita Y, Uda S, Motosugi R, Hamazaki J, Kubota H, Murata S, Tanaka K, Katagiri T, Kosako T, Takahama Y.
Trans-omics impact of thymoproteasome in cortical thymic epithelial cells
Cell Rep 29:2901-2916 (2019)
Khanom U.S, Ohigashi I, Fujimori S, Kondo K, Takada K, Takahama Y.
TCR affinity for in vivo peptide-induced thymic positive selection fine-tunes TCR responsiveness of peripheral CD8+ T cells.
J Immunol 203:881-887 (2019)
Cowan JE, Malin J, Zhao Y, Seedhom MO, Harly C, Ohigashi I, Kelly M, Takahama Y, Yewdell JW, Cam M, Bhandoola A.
Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth.
Nat Commun 10:5498 (2019)
Kondo K, Ohigashi I,Takahama Y.
Thymus machineries for T cell selection.
Int Immunol 31:119-125 (2019)
Takahama Y, Ohigashi I, Murata S, Tanaka K.
Thymoproteasome and peptidic self.
Immunogenetics 71:217-221 (2019)
[2018]
Sakata M, Ohigashi I, Takahama Y.
Cellularity of thymic epithelial cells in the postnatal mouse.
J Immunol. 200:1382-1388 (2018) [read In This Issue]
Takeuchi A, Ozawa M, Kanda Y, Kozai M, Ohigashi I, Kurosawa Y, Rahman MA, Kawamura T, Shichida Y, Umemoto E, Miyasaka M, Ludewig B, Takahama Y, Nagasawa T, Katakai T.
A distinct subset of fibroblastic stromal cells constitutes the cortex-medulla boundary subcompartment of the lymph node.
Front Immunol. 9:2196 (2018)
Cosway EJ, Ohigashi I, Schauble K, Parnell SM, Jenkinson WE, Luther S, Takahama Y, Anderson G.
Formation of the intrathymic dendritic cell pool requires CCL21-mediated recruitment of CCR7+ progenitors to the thymus.
J Immunol. 201:516-523 (2018)
Murata S, Takahama Y, Kasahara M, Tanaka K.
The immunoproteasome and thymoproteasome: Function, evolution, and human disease.
Nat Immunol.19:923-931 (2018)
[2017]
Kozai M, Kubo Y, Katakai T, Kondo H, Kiyonari H, Schaeuble K, Luther SA, Ishimaru N, Ohigashi I, Takahama Y.
Essential role of CCL21 in establishment of central self-tolerance in T cells.
J Exp Med. 214:1925-1935 (2017)
Ohigashi I, Ohte Y, Setoh K, Nakase H, Maekawa A, Kiyonari H, Hamazaki Y, Sekai M, Sudo T, Tabara Y, Sawai H, Omae Y, Yuliwulandari R, Tanaka Y, Mizokami M, Inoue H, Kasahara M, Minato N, Tokunaga K, Tanaka K, Matsuda F, Murata S, Takahama Y.
A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production.
JCI Insight. 2:93664 (2017)
Uddin MM, Ohigashi I, Motosugi R, Nakayama T, Sakata M, Hamazaki J, Nishito Y, Rode I, Tanaka K, Takemoto T, Murata S, Takahama Y.
Foxn1-β5t transcriptional axis controls CD8+ T cell production in the thymus.
Nature Commun. 8:14419 (2017)
Sornborger A, Li J, Timmons C, Lupu F, Eggenschwiler J, Takahama Y, Manley NR.
MiCASA is a new method for quantifying cellular organization.
Nature Commun. 8:15619 (2017)
Takahama Y, Ohigashi I, Baik S, Anderson G.
Generation of diversity in thymic epithelial cells.
Nature Rev Immunol. 17:295-305 (2017)
Takada K, Kondo K, Takahama Y.
Generation of peptides that promote positive selection in the thymus.
J Immunol. 198:2215-2222 (2017)
Kondo K, Takada K, Takahama Y.
Antigen processing and presentation in the thymus: Implications for T cell repertoire selection.
Curr Op Immunol. 46:53-67 (2017)
Cossarizza A, Chang HD, Radbruch A, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J.
Guidelines for the use of flow cytometry and cell sorting in immunological studies.
Eur J Immunol. 47:1584-1797 (2017)
[2016]
Ohigashi I, Kozai M, Takahama Y.
Development and developmental potential of cortical thymic epithelial cells.
Immunol Rev. 271:10-22 (2016)
Mayer CE, Zuklys S, Zhanybekova S, Ohigashi I, Teh HY, Sansom SN, Shikama-Dorn N, Hafen K, Macaulay IC, Deadman ME, Ponting CP, Takahama Y, Holländer GA.
Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla.
Eur J Immunol. 46:846-856 (2016)
Ohigashi I, Takahama Y.
Flow cytometric analysis of thymic epithelial cells and their subpopulations.
Methods Mol Biol. 1323:65-73 (2016)
Ohigashi I, Takahama Y.
Thymocyte-mTEC cross talk for self-tolerance in T cells.
Encyclopedia of Immunobiology. Academic Press, ISBN 9780123742797, page 263-267 (2016)
Watanabe T, Takahama Y.
Synthetic Immunology.
Springer ISBN 978-4-431-56025-8 (2016)
[2015]
Takada K, Van Laethem F, Xing Y, Akane K, Suzuki H, Murata S, Tanaka K, Jameson SC, Singer A, Takahama Y.
TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8+ T cells.
Nature Immunol. 16:1069-1076 (2015)
Ohigashi I, Zyklys S, Sakata M, Mayer CE, Hamazaki Y, Minato N, Hollander GA, Takahama Y.
Adult thymic medullary epithelium is maintained and regenerated by lineage-restricted cells rather than bipotent progenitors.
Cell Reports. 13:1432-1443 (2015)
Sasaki K, Takada K, Ohte Y, Kondo H, Sorimachi H, Tanaka K, Takahama Y, Murata S.
Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells.
Nature Commun. 6:7484 (2015) [read a highlight in Nature Immunology]
Sano T, Iwashita M, Nagayasu S, Yamashita A, Shinjo T, Hashikata A, Asano T, Kushiyama A, Ishimaru N, Takahama Y, Nishimura F.
Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling.
Obesity. 23:1460-1471 (2015)
Takada K, Takahama Y.
Positive selection-inducing self-peptides displayed by cortical thymic epithelial cells.
Adv Immunol. 125:87-110 (2015)
[2014]
Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, Ishimaru N, Takada K, Butcher GW, Takahama Y.
Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.
Eur J Immunol. 44:561-572 (2014) [read a commentary by Ciucci and Bosselut]
Togoo K, Takahama Y, Takada K.
Alpha-smooth muscle actin expression identifies subpopulations of lymph node non-hematopoietic cells.
Biochem Biophys Res Commun. 449:241-247 (2014)
Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.
Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28–CD80/86 and CD40–CD40L costimulatory pathways.
J Immunol. 192:630-640 (2014)
Matsui N, Ohigashi I, Tanaka K, Nakagawa Y, Kondo K, Kitagawa T, Yamashita S, Nomura Y, Takahama Y, Kaji R.
Increased number of Hassall's corpuscles in myasthenia gravis patients carrying thymic hyperplasia.
J Neuroimmunol. 269:56-61 (2014)
Ohigashi I, Takahama Y.
CCRL1 marks heterogeneity in cortical and medullary thymic epithelial cells.
Eur J Immunol. 44:2872-2875 (2014)
Alves NL, Takahama Y, Ohigashi I, Ribeiro AR, Baik S, Anderson G, Jenkinson WE.
Serial progression of cortical and medullary thymic epithelial microenvironments.
Eur J Immunol. 44:16-22 (2014)
Takada K, Ohigashi I, Kasai M, Nakase H, Takahama Y.
Development and function of thymic cortical epithelial cells.
Curr Top Microbiol Immunol. 373:1-17 (2014)
Kasai M, Nakagawa Y, Kondo K, Takahama Y.
Thymus.
Reference Module in Biomedical Sciences. doi:10.1016/B978-0-12-801238-3.00109-4 (2014)
Boehm T,Takahama Y.
Thymic development and selection of T lymphocytes.
Springer ISBN 978-3-642-40252-4 (2014)
[2013]
Ohigashi I, Zuklys S, Sakata M, Mayer CE, Zhanybekova S, Murata S, Tanaka K, Hollander GA, Takahama Y.
Aire-expressing thymic medullary epithelial cells originate from beta5t-expressing progenitor cells.
Proc Natl Acad Sci USA. 110:9885-9890 (2013)[read a commentary in Asian Scientist]
Lkhagvasuren E, Sakata M, Ohigashi I, Takahama Y.
Lymphotoxin beta receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells.
J Immunol. 190:5110-5117 (2013)
Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak MJ, Zuklys S, Sharrow SO, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander G, Takahama Y, Hodes RJ.
Traf3 enforces the requirement for T cell crosstalk in thymic medullary epithelial development.
Proc Natl Acad Sci USA. 110:21107-21112 (2013)
Kurobe H, Tominaga T, Sugano M, Hayabuchi Y, Egawa Y, Takahama
Y, Kitagawa T.
Complete but not partial thymectomy in early infancy reduces
T-cell-mediated immune responses: Three-year-tracing study after pediatric
cardiac surgery.
J Thorac Cardiovasc Surg. 145:656-662 (2013)
Bryson JL, Griffith AV, Hughes B, Saito F, Takahama Y, Richie ER, Manley NR.
Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus.
PLoS One. 8(6):e65196 (2013)
Nakayama T, Kurobe H, Sugasawa N, Kinoshita H, Higashida M, Matsuoka Y, Yoshida Y, Hirata Y, Sakata M, Maxfield M, Shimabukuro M, Takahama Y, Sata M, Tamaki T, Kitagawa T, Tomita S.
Role of macrophage-derived hypoxia-inducible factor (HIF)-1a as a mediator of vascular remodeling.
Cardiovascular Research. 99:705-715 (2013)
Nitta T, Ohigashi
I, Takahama Y.
The development of T lymphocytes in fetal thymus organ culture.
Methods Mol
Biol. 946:85-102
(2013)
[2012]
Nakagawa Y, Ohigashi I, Nitta
T, Sakata M, Tanaka K, Murata S, Kanagawa O, Takahama
Y.
Thymic nurse cells provide microenvironment for secondary TCRƒ¿ rearrangement
in cortical thymocytes.
Proc
Natl Acad Sci USA. 109:20572-20577
(2012)
Roberts NM, White AJ, Jenkinson WE, Turchinovich
G, Nakamura K, Withers DR, McConnell FM, Desanti GE, Benezech C, Parnell
SM,
Cunningham
AF,Paolino M, Penninger J, Simon K, Nitta T, Ohigashi
I, Takahama Y, Caamano JH, Hayday AC, Lane PJ,
Jenkinson EJ, Anderson G.
Rank signaling links the development of invariant ƒÁƒÂ T cell progenitors
and Aire+ medullary epithelium.
Immunity.
36:427-437 (2012)
Zuklys S, Mayer CE, Zhanybekova S, Stefanski H, Nusspaumer
G, Gill J, Barthlott T, Chappaz S, Nitta T, Dooley J, Nogales-Caballero
R, Takahama Y, Finke D, Liston A, Blazar BR, Pascual-Montano
A, Hollander GA.
miRNAs control the maintenance of thymic epithelia and their competence for T
lineage committment and thymocyte selection.
J Immunol. 189:3894-3904
(2012)
Ishimaru
N, Yamada A, Nitta T, Arakaki R, Lipp M, Takahama
Y, Hayashi Y.
CCR7 with S1P1 signaling through AP1 for migration of Foxp3+ regulatory T cells
controls autoimmune exocrinopathy.
Am J Pathol. 180:199-208
(2012)
Anderson G, Takahama Y.
Thymic epithelial cells: working class heroes for T cell development and repertoire
selection.
Trends
Immunol. 33:256-263
(2012)
Takahama Y, Takada K, Murata
S, Tanaka K.
Beta5t-containing thymoproteasome: specific expression in thymic cortical
epithelial cells and role in positive selection of CD8+ T cells.
Curr Op Immunol. 24:92-98
(2012)
Lei Y, Takahama Y.
XCL1 and XCR1 in the immune system.
Microbes and
Infection. 14:262-267
(2012)
[2011]
Lei Y, Mat
Ripen A, Ishimaru N, Ohigashi I, Nagasawa
T, Jeker L, Bosl M, Hollander GA, Hayashi Y, de Waal Malefyt R, Nitta
T, Takahama Y.
Aire-dependent production of XCL1 mediates medullary accumulation
of thymic dendritic cells and contributes to regulatory T cell development.
J
Exp Med. 208:383-394
(2011) [read
Research
Highlight in NRI] [read
Research
Highlight in NI]
Mat Ripen A, Nitta T, Murata
S, Tanaka K, Takahama Y.
Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit
beta5t.
Eur J Immunol. 41:1278-1287
(2011)
Ohigashi I, Nitta T, Lkhagvasuren
E, Yasuda H, Takahama Y.
Effects of RANKL on the thymic medulla.
Eur
J Immunol. 41:1822-1827
(2011)
Takahama Y.
Medullary interplay for central tolerance
Blood. 118:2380-2381
(2011)
Nitta
T, Ohigashi I, Nakagawa Y, Takahama Y.
Cytokine crosstalk for thymic medulla formation.
Curr
Op Immunol. 23:190-197
(2011)
Yamano T, Watanabe
S, Hasegawa H, Suzuki T, Abe R, Tahara H, Nitta
T, Ishimaru
N, Sprent J, Kishimoto H.
Ex vivo-expanded
DCs induce donor-specific central and peripheral tolerance and prolong the
acceptance of donor skin grafts.
Blood. 117:2640-2648 (2011)
[2010]
Nitta T, Murata S, Sasaki K, Fujii H, Mat
Ripen A, Ishimaru N, Koyasu S, Tanaka K, Takahama Y.
Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells.
Immunity. 32:29-40
(2010) [read the
Preview in Immunity]
Ohigashi I, Yamazaki Y, Hirashima T, Takahama
Y.
Identification of the transgenic integration site in immunodeficient tgε26 human
CD3ε transgenic mice.
PLoS One. 5(12):e14391
(2010)
White AJ, Nakamura K, Saini M, Sinclair C, Seddon B, Narendran
P, Pfeffer K, Nitta T, Takahama Y, Caamano
JH, Lane PJ, Jenkinson EJ, Anderson G.
Lymphotoxin signals from positively selected thymocytes regulate the terminal
differentiation of medullary thymic epithelial cells.
J Immunol. 185:4769-4776
(2010)
Matsui N, Nakane S, Saito F, Ohigashi
I, Nakagawa Y, Kurobe H, Takizawa H, Mitsui T, Kondo K, Kitagawa
T, Takahama Y, Kaji R.
Undiminished regulatory T cells in the thymus of patients with myasthenia gravis.
Neurology. 74:816-820
(2010) [read the
Correspondence]
Hidaka K, Nitta T, Sugawa R, Shirai M, Schwartz
RJ, Amagai T, Nitta S, Takahama Y, Morisaki
T.
Differentiation of pharyngeal endoderm from mouse embryonic stem cell.
Stem Cells Dev. 19:1735-1743
(2010)
Ishimaru N, Nitta T, Arakaki R, Yamada A,
Lipp M, Takahama Y, Hayashi Y.
In situ patrolling of regulatory T cells is essential for protecting autoimmune
exocrinopathy.
PLoS One. 5(1):e8588 (2010)
Kurobe H, Urata M, Ueno M, Ueki M, Ono S,
Izawa-Ishizawa Y, Fukuhara Y, Lei Y, Mat Ripen A,
Kanbara T, Aihara K, Ishizawa K, Akaike M, Gonzalez FJ, Tamaki T, Takahama
Y, Yoshizumi M, Kitagawa T, Tomita S.
Role of HIF-1α in T cells as a negative regulator in development of vascular
remodeling.
Arteriosclerosis
Thrombosis and Vascular Biology. 30:210-217
(2010)
Tosa N, Iwai A, Tanaka T, Kumagai T, Nitta T,
Chiba S, Maeda M, Takahama Y, Uede T, Miyazaki T.
Critical function of death associated protein 3 in T cell receptor mediated-apoptosis
induction.
Biochem Biophys
Res Commun.395:356-360
(2010)
Takahama Y, Nitta T, Mat
Ripen A, Nitta S, Murata S, Tanaka K.
Role of thymic cortex-specific self-peptides in positive selection of T cells.
Sem Immunol. 22:287-293
(2010)
Takada K, Takahama Y.
Another zinc finger in the pie of CD4-CD8 lineage choice.
Nature Immunol. 11:370-371
(2010)
Takahama Y, Miyasaka M.
Top three reasons to come to Kobe for the 14th International Congress of
Immunology.
Eur J Immunol. 40:10-11
(2010)
[2009]
Nitta T, Nitta S, Lei Y, Lipp M, Takahama
Y.
CCR7-mediated medulla migration of developing thymocytes is essential
for negative selection to tissue-restricted antigens.
Proc
Natl Acad Sci USA. 106:17129-17133
(2009)
Sultana DA, Tomita S, Hamada
M, Iwanaga Y, Kitahama Y, Khang
NV, Hirai S, Ohigashi I, Nitta
S, Amagai T, Takahashi S, Takahama Y.
Gene expression profile of third pharyngeal pouch reveals role of mesenchymal
MafB in embryonic thymus development.
Blood. 113:2976-2987 (2009)
Lei Y, Liu C, Saito
F, Fukui Y, Takahama Y.
Role of DOCK2 and DOCK180 in fetal thymus
colonization.
Eur J Immunol. 39:
2695-2702 (2009) [read In This
Issue] [see the Cover]
Iwanami
N, Okada M, Hoa
VQ, Seo Y, Mitani H, Sasaki T, Shimizu N, Kondoh
H, Furutani-Seiki M, Takahama Y.
Ethylnitrosourea-induced thymus-defective mutants identify roles of KIAA1440,
TRRAP, and SKIV2L2 in teleost organ development.
Eur J Immunol. 39:2606-2616
(2009) [read In This Issue] [see the
Cover]
Martin AP, Marinkovic T, Canasto-Chibuque C, Latif R, Unkeless
JC, Davies T, Takahama Y, Furtado GC, Lira SA.
CCR7 deficiency in NOD mice leads to thyroiditis and primary hypothyroidism.
J
Immunol. 183:3073-3080
(2009)
Nitta T, Takahama Y.
Toward understanding how the immune system establishes a diverse yet self-tolerant
T-cell repertoire: stepwise roles of thymic microenvironments.
Systems Biology: The Challenge of
Complexity. eds. Nakanishi S,
Kageyama R, Watanabe D. Springer Tokyo. p 71-82 (2009)
Takahama Y, Saito T, Kawamoto H, Itoi M, Boyd
RL, Chidgey A, Zamoyska R, Hollander GA, Anderson G, Taylor N, Petrie HT,
Nikolich-Zugich
J.
The global thymus network: past, present, and future.
Trends Immunol. 30:191-192
(2009)
[2008]
Hikosaka Y, Nitta T, Ohigashi
I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M,
Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue
J, Akiyama T, Takahama Y.
The cytokine RANKL produced by positively selected thymocytes fosters medullary
thymic epithelial cells that express autoimmune regulator.
Immunity. 29:438-450 (2008) [read the
Preview in Immunity]
Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima, D, Maruyama Y,
Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Matsumoto M, Nitta
T, Takahama Y, Inoue J.
The tumor necrosis factor family receptors RANK and CD40 cooperatively
establish the thymic medullary microenvironment and self-tolerance.
Immunity. 29:423-437
(2008) [read the
Preview in Immunity]
Irla M, Hugues S, Gill J, Nitta T, Hikosaka
Y, Williams IR, Hubert FX, Scott HS, Takahama Y,
Hollander GA, Reith W.
Autoantigen-specific interactions with CD4+ thymocytes control mature medullary
thymic epithelial cell cellularity.
Immunity. 29:451-463
(2008) [read the
Preview in Immunity]
Iwanami N, Higuchi T, Sasano
Y, Fujiwara T, Hoa V, Okada M, Talukder
S, Kunimatsu S, Li J, Saito
F, Bhattacharya C, Matin A, Sasaki T, Shimizu N, Mitani H, Himmelbauer
H, Momoi, A, Kondoh H, Furutani-Seiki M, Takahama Y.
WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle progression,
and teleost organ development.
PLoS Genetics. 4(8):e1000171
(2008)
Takahama Y, Tanaka K, Murata S.
Modest cortex and promiscuous medulla for thymic repertoire formation.
Trends
Immunol. 29:251-255
(2008)
Murata S, Takahama Y, Tanaka K.
Thymoproteasome: probable role in generating positively selecting peptides.
Curr Op Immunol. 20:192-196
(2008)
Nitta T, Murata S, Ueno T,
Tanaka K, Takahama Y.
Thymic microenvironments for T-cell repertoire formation.
Adv Immunol. 99:59-94
(2008)
Takahama Y, Miyasaka M.
One small step
for immunologists.
Eur J Immunol. 38:2056-2057 (2008)
[2007]
Li J, Iwanami N, Hoa VQ, Furutani-Seiki
M, Takahama
Y.
Noninvasive intravital imaging of thymocyte dynamics
in medaka.
J
Immunol. 179:1605-1615 (2007)
Murata S, Sasaki K, Kishimoto T, Niwa S, Hayashi H, Takahama
Y, Tanaka K.
Regulation of CD8+ T cell development by thymus-specific proteasomes.
Science. 316:1349-1353 (2007) [see the
PERSPECTIVE by Bevan] [read the
RESEARCH HIGHLIGHT in NI] [read the
RESEARCH HIGHLIGHT in
NRI]
Rossi S, Jeker LT, Ueno T, Kuse S, Keller
MP, Zuklys A, Gudkov A, Takahama Y, Krenger W, Blazar BR, Hollander
GA.
Keratinocyte growth factor enhances post-natal T cell development via improvement
in proliferation and function of thymic epithelial cells.
Blood. 109:3803-3811
(2007) [see the
COMMENTS by Chu & Hakim]
Yasuda T, Kuwabara T, Nakano H, Aritomi K, Onodera T, Lipp
M, Takahama Y, Kakiuchi T.
Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding
T cells.
Blood. 109:449-456
(2007)
Jenkinson WE, Rossi SW, Parnell SM, Agace WW, Takahama Y,
Jenkinson EJ, Anderson G.
Chemokine receptor expression defines heterogeneity in the earliest
thymic migrants.
Eur
J Immunol. 37:2090-2096 (2007)
Hagiwara H, Sawakami-Kobayashi K, Yamamoto M,
Iwasaki S, Sugiura M, Abe H, Kunihiro-Ohashi S, Takase K, Yamane N,
Kato K, Son R, Nakamura M, Segawa O, Yoshida M, Yohda M, Tajima H,
Kobori M, Takahama Y, Itakura M, Machida M.
Development of an automated SNP analysis method using a paramagnetic
beads handling robot.
Biotechnol
Bioeng. 98:420-428 (2007)
Nitta T, Takahama Y.
The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family
proteins.
Trends
Immunol. 28:58-65 (2007) [see the COVER]
Liu C, Takahama Y.
Development of helper and regulatory CD4+ T cells in the thymus.
Effector
CD4+ T Cells in Health and Disease. eds.
Na S, Venkataraman C. Transworld Research Network. p 1-12 (2007)
Takahama Y, Kawamoto H, Toyama-Sorimachi N, Miyasaka
M.
Japanese Society for Immunology goes public: immunology outreach in Japan.
Eur
J
Immunol. 37:1717-1719 (2007)
Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa
H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita
S, Molkentin JD, Zou Y, Komuro I.
p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload.
Nature. 446:444-448
(2007)
Izawa Y, Yoshizumi M, Ishizawa K, Fujita Y, Kondo S, Kagami
S, Kawazoe K, Tsuchiya K, Tomita S, Tamaki T.
Big mitogen-activated protein kinase1 (BMK1)/ extracellular signal regulated
kinase 5 (ERK5) is involved in platelet-derived growth factor (PDGF)-induced
vascular smooth muscle cell migration.
Hypertens Res 30:1107-1117 (2007)
[2006]
Kurobe H, Liu
C, Ueno T, Saito F, Ohigashi I, Seach N, Arakaki
R, Hayashi Y, Kitagawa T, Lipp M, Boyd RL, Takahama Y.
CCR7-dependent cortex-to-medulla migration of positively selected thymocytes
is essential for establishing central tolerance.
Immunity. 24:165-177
(2006) [read the RESEARCH HIGHLIGHT in NI
Nitta T, Nasreen
M, Seike T, Goji A, Ohigashi I, Miyazaki T,
Ohta T, Kanno M, Takahama Y.
IAN family critically regulates survival and development of T
lymphocytes.
PLoS
Biology. 4(4):e103 (2006) [read the
SYNOPSIS by C Sedwick] [read the
RESEARCH HIGHLIGHT in NRI]
Liu C, Saito F, Liu Z, Lei Y, Uehara S,
Love PE, Lipp M, Kondo S, Manley NR, Takahama Y.
Coordination between CCR7- and CCR9-mediated chemokine signals in
pre-vascular fetal thymus colonization.
Blood. 108:2531-2539
(2006) [the
COVER for BLOOD] [read the COMMENT by G.
Anderson]
Tomita S, Maekawa SI, Rahman
M, Saito F, Kizu R, Tohi K, Ueno T, Nakase H,
Gonzalez FJ, Hayakawa K, Korenaga T, Takahama Y.
Thymic involution produced by diesel exhaust
particles and their constituents in mice.
Toxicological
and Environmental Chemistry. 88:113 - 124
(2006)
Takahama Y.
Journey through the thymus: stromal guides for T-cell development and
selection.
Nature
Rev Immunol. 6:127-135
(2006)
Hollander G, Gill J, Zuklys S, Iwanami
N, Liu C, Takahama Y.
Cellular and molecular events during early thymus development.
Immunol
Rev. 209:28-46
(2006)
Ramsdell F, Zuniga-Pflucker JC, Takahama Y.
In vitro systems for the
study of T cell development: fetal thymus organ culture and OP9-DL1
cell coculture.
Current
Protocols
in Immunology. 3.18.1-18 (2006)
Yim SH, Shah Y, Tomita
S, Morris HD, Gavrilova O, Lambert G, Ward
JM, Gonzalez FJ.
Disruption of the Arnt gene in endothelial cells causes hepatic
vascular defects and partial embryonic lethality.
Hepatology.
44:550-560 (2006)
Ueno M, Tomita S,
Nakagawa T, Ueki M, Iwanaga
Y, Ono J, Onodera M, Huang CL, Kanenishi K, Shimada A,
Maekawa N, Sakamoto H.
Effects of aging and HIF-1alpha deficiency on permeability of
hippocampal vessels.
Microsc
Res Tech. 69:29-35
(2006)
Ueno M, Tomita S,
Ueki M, Iwanaga
Y, Huang CL, Onodera M,
Maekawa N, Gonzalez FJ, Sakamoto H.
Two pathways of apoptosis are simultaneously induced in the embryonal
brains of neural cell-specific HIF-1alpha-deficient mice.
Histochem
Cell Biol. 125:535-544
(2006)
[2005]
Liu C, Ueno
T, Kuse S, Saito
F, Nitta T, Piali L, Nakano H, Kakiuchi T, Lipp M, Hollander
GA, Takahama
Y.
The role of CCL21 in recruitment of T-precursor cells to fetal
thymi.
Blood. 105:31-39
(2005) [read the
RESEARCH HIGHLIGHT IN BRIEF in
NRI]
Gray DHD, Ueno
T, Chidgey AP, Malin M, Goldberg GL, Takahama Y, Boyd RL.
Controlling the thymic microenvironment.
Curr
Op Immunol. 17:137-143 (2005)
Ueno T, Liu C,
Nitta T, Takahama Y.
Development of T-lymphocytes in mouse fetal thymus organ culture.
Methods
Mol Biol. 290:117-134
(2005)
Kuroda
N, Mitani T, Takeda N, Ishimaru N, Arakaki R, Hayashi Y, Bando Y, Izumi
K, Takahashi T,
Nomura T, Sakaguchi S, Ueno
T, Takahama Y, Uchida D, Sun S, Kajiura F, Mouri Y, Han H,
Matsushima A, Yamada G, Matsumoto M.
Development of autoimmunity against transcriptionally unrepressed
target antigen in the thymus from Aire-deficient mice.
J
Immunol. 174:1862-1870
(2005)
Izawa Y, Yoshizumi M, Fujita Y, Ali N, Kanematsu
Y, Ishizawa K, Tsuchiya K, Obata T, Ebina Y, Tomita
S, Tamaki T.
ERK1/2 activation by angiotensin II inhibits insulin-induced glucose uptake in
vascular smooth muscle cells.
Exp
Cell Res. 308:291-299
(2005)
[2004]
Ueno T, Saito F,
Gray DH, Kuse
S, Hieshima K, Nakano H,
Kakiuchi T, Lipp M, Boyd RL, Takahama Y.
CCR7 signals are essential for cortex-to-medulla migration of
developing thymocytes.
J
Exp Med. 200:493-505
(2004) [read the
COMMENTARY by C Witt & E Robey] [read
the RESEARCH
HIGHLIGHT in NRI]
Sheard MA, Liu
C, Takahama Y.
Developmental status of CD4-CD8+ and CD4+CD8- thymocytes with medium expression
of CD3.
Eur
J Immunol. 34:25-35 (2004)
Talukder SR,
Dudley DD, Alt FW, Takahama Y, Akamatsu
Y.
Increased frequency of aberrant V(D)J recombination products in core RAG-expressing
mice.
Nucleic
Acids Res. 32:4539-4549
(2004)
Iwanami N, Takahama Y, Kunimatsu
S, Li J, Takei
R, Ishikura Y, Suwa H, Niwa K, Sasado T, Morinaga C, Yasuoka A,
Deguchi T, Hirose Y, Yoda H, Henrich T, Ohara O, Kondoh H,
Furutani-Seiki M.
Mutations affecting thymus organogenesis in medaka, Oryzias
latipes.
Mech
Dev. 121:779-789 (2004)
Furutani-Seiki M, Sasado T, Morinaga C, Suwa H,
Niwa K, Yoda H, Deguchi T, Hirose Y, Yasuoka A, Henrich T, Watanabe
T, Iwanami N,
Kitagawa D, Saito K, Asaka S, Osakada M, Kunimatsu S, Momoi A, Elmasri H,
Winkler C, Ramialison M, Loosli F, Quiring R, Carl M, Grabher C,
Winkler S, Del Bene F, Shinomiya A, Kota Y, Yamanaka T, Okamoto Y,
Takahashi K, Todo T, Abe K, Takahama
Y, Tanaka M, Mitani H, Katada T, Nishina
H, Nakajima N, Wittbrodt J, Kondoh H.
A systematic genome-wide screen for mutations affecting organogenesis
in Medaka, Oryzias latipes.
Mech
Dev. 121:647-658 (2004)
Watanabe T, Asaka S, Kitagawa D, Saito K,
Kurashige R, Sasado T, Morinaga C, Suwa H, Niwa K, Henrich T, Hirose
Y, Yasuoka A, Yoda H, Deguchi T, Iwanami
N, Kunimatsu
S, Osakada M, Loosli F, Quiring R, Carl M,
Grabher C, Winkler S, Del Bene F, Wittbrodt J, Abe K, Takahama Y, Takahashi K, Katada
T, Nishina H, Kondoh H, Furutani-Seiki M.
Mutations affecting liver development and function in Medaka, Oryzias
latipes.
Mech
Dev. 121:791-802 (2004)
Elmasri H, Winkler C, Liedtke D, Sasado T,
Morinaga C, Suwa H, Niwa K, Henrich T, Hirose Y, Yasuoka A, Yoda H,
Watanabe T, Deguchi T, Iwanami
N, Kunimatsu
S, Osakada M, Loosli F, Quiring R, Carl M,
Grabher C, Winkler S, Del Bene F, Wittbrodt J, Abe K, Takahama Y, Takahashi K, Katada
T, Nishina H, Kondoh H, Furutani-Seiki M.
Mutations affecting somite formation in the Medaka (Oryzias
latipes).
Mech
Dev. 121:659-671 (2004)
Sasado T, Morinaga C, Niwa K,
Shinomiya A, Yasuoka A, Suwa H, Hirose Y, Yoda H, Henrich T, Deguchi
T, Iwanami
N, Watanabe T,
Kunimatsu S, Osakada M, Okamoto Y, Kota Y, Yamanaka T,
Tanaka M, Kondoh H, Furutani-Seiki M.
Mutations affecting early distribution of primordial germ cells in
Medaka (Oryzias latipes) embryo.
Mech
Dev. 121:817-828 (2004)
Morinaga C, Tomonaga T, Sasado T, Suwa H, Niwa K,
Yasuoka A, Henrich T, Watanabe T, Deguchi T, Yoda H, Hirose Y,
Iwanami N,
Kunimatsu S,
Okamoto Y, Yamanaka T, Shinomiya A, Tanaka M, Kondoh H,
Furutani-Seiki M.
Mutations affecting gonadal development in Medaka, Oryzias
latipes.
Mech
Dev. 121:829-839 (2004)
Yasuoka A, Hirose Y, Yoda H, Aihara Y, Suwa H,
Niwa K, Sasado T, Morinaga C, Deguchi T, Henrich T, Iwanami N, Kunimatsu S, Abe K, Kondoh H,
Furutani-Seiki M.
Mutations affecting the formation of posterior lateral line system in
Medaka, Oryzias latipes.
Mech
Dev. 121:729-738 (2004)
Yoda H, Hirose Y, Yasuoka A, Sasado T, Morinaga C,
Deguchi T, Henrich T, Iwanami
N, Watanabe T, Osakada M, Kunimatsu S, Wittbrodt J, Suwa
H, Niwa K, Okamoto Y, Yamanaka T, Kondoh H, Furutani-Seiki M.
Mutations affecting retinotectal axonal pathfinding in Medaka,
Oryzias latipes.
Mech
Dev. 121:715-728 (2004)
Loosli F, Bene FD, Quiring R, Rembold M,
Martinez-Morales JR, Carl M, Grabher C, Iquel C, Krone A, Wittbrodt
B, Winkler S, Sasado T, Morinaga C, Suwa H, Niwa K, Henrich T,
Deguchi T, Hirose Y, Iwanami
N, Kunimatsu
S, Osakada M, Watanabe T, Yasuoka A, Yoda
H, Winkler C, Elmasri H, Kondoh H, Furutani-Seiki M, Wittbrodt J.
Mutations affecting retina development in Medaka.
Mech
Dev. 121:703-714 (2004)
Kitagawa D, Watanabe T, Saito K, Asaka S, Sasado
T, Morinaga C, Suwa H, Niwa K, Yasuoka A, Deguchi T, Yoda H, Hirose
Y, Henrich T, Iwanami N, Kunimatsu S, Osakada M, Winkler C, Elmasri H, Wittbrodt J, Loosli F,
Quiring R, Carl M, Grabher C, Winkler S, Del Bene F, Momoi A, Katada
T, Nishina H, Kondoh H, Furutani-Seiki M.
Genetic dissection of the formation of the forebrain in Medaka,
Oryzias latipes.
Mech
Dev. 121:673-685 (2004)
Aizawa K, Mitani H, Kogure N, Shimada A, Hirose Y,
Sasado T, Morinaga C, Yasuoka A, Yoda H, Watanabe T, Iwanami N, Kunimatsu S, Osakada M, Suwa H,
Niwa K, Deguchi T, Hennrich T, Todo T, Shima A, Kondoh H,
Furutani-Seiki M.
Identification of radiation-sensitive mutants in the Medaka, Oryzias
latipes.
Mech
Dev. 121:895-902 (2004)
Kajiura F, Sun S, Nomura T, Izumi
K, Ueno T,
Bando Y, Kuroda N, Han H, Li Y,
Matsushima A, Takahama
Y, Sakaguchi S, Mitani T,
Matsumoto M.
NF-kB-inducing kinase establishes self-tolerance in a thymic-stroma dependent
manner.
J
Immunol. 172:2067-2075
(2004)
Wu RF, Liao CX, Tomita S, Ichikawa Y,
Terada LS.
Porcine FAD-containing monooxygenase metabolizes lidocaine, bupivacaine and
propranolol in vitro.
Life Sci. 75:1011-1019 (2004)
[2003]
Tomita S,
Jiang HB, Ueno T,
Takagi S, Tohi
K, Maekawa S, Miyatake A, Furukawa A, Gonzalez FJ, Takeda J, Ichikawa
Y, Takahama
Y.
T cell-specific disruption of aryl hydrocarbon receptor nuclear translocator
gene causes resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced thymic
involution.
J
Immunol. 171:4113-4120
(2003)
Nasreen M, Ueno T,
Saito F, Takahama Y.
In vivo treatment of class II MHC-deficient mice with anti-TCR
antibody restores the generation of circulating CD4 T cells and
optimal architecture of thymic medulla.
J
Immunol. 171:3394-3400
(2003)
Akamatsu Y,
Monroe R, Dudley DD, Elkin SK, Gartner F, Talukder SR, Takahama
Y, Alt FW, Bassing CH, Oettinger MA.
Deletion of the RAG2 C-terminus leads to impaired lymphoid
development in mice.
Proc
Natl Acad Sci USA. 100:1209-1214 (2003)
Nakase H, Takahama Y, Akamatsu
Y.
Effect of CpG methylation on RAG1/RAG2 reactivity: implications of
direct and indirect mechanism for controlling V(D)J cleavage.
EMBO
R. 4:774-780
(2003)
Tomita S,
Ueno M, Sakamoto M, Kitahama Y, Ueki M, Maekawa N, Sakamoto H, Gassmann
M, Kageyama
R, Ueda N, Gonzalez FJ, Takahama Y.
Defective brain development in mice lacking HIF-1 alpha in neural
cells.
Mol
Cell Biol. 23:6739-6749
(2003)
Takagi S, Tojo H, Tomita
S, Sano S, Itami S, Hara M, Inoue S, Horie K, Kondoh G, Hosokawa
K, Gonzalez FJ, Takeda J.
Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific
Arnt-deficient mice affects skin barrier
function.
J
Clin Invest. 112:1372-82
(2003)
[2002]
Ueno T, Hara K,
Willis MS, Malin MA, Hopken UE, Gray DH, Matsushima K, Lipp M,
Springer TA, Boyd RL, Yoshie O, Takahama Y.
Role for CCR7 ligands in the emigration of newly generated T
lymphocytes from the neonatal thymus.
Immunity. 16:205-218 (2002) [read the
RESEARCH HIGHLIGHT IN
BRIEF in NRI]
[2001]
Sano S, Takahama Y, Sugawara
T, Kosaka H, Itami S,
Yoshikawa K, Miyazaki J, van Ewijk W, Takeda J.
Stat3 in thymic epithelial cells is essential for postnatal
maintenance of thymic architecture and thymocyte survival.
Immunity. 15:261-273
(2001) [read the
RESEARCH HIGHLIGHT in
NRI]
Tada M, Takahama Y, Abe K, Nakatsuji N, Tada T.
Nuclear reprogramming of somatic cells by in vitro hybridization with
ES cells.
Current
Biology. 11:1553-1558
(2001)
Masuyama N, Oishi K, Mori Y, Ueno T, Takahama Y, Gotoh Y.
Akt inhibits the orphan nuclear receptor Nur77 and T cell
apoptosis.
J
Biol Chem. 276:32799-32805
(2001)
Yoh K, Sugawara T, Motohashi H, Takahama Y, Koyama A, Yamamoto M, Takahashi
S.
Transgenic overexpression of MafK suppresses T cell proliferation and function
in vivo.
Genes
to Cells. 6:1055-1066
(2001)
Takahama Y.
Genetic modulation of immature T lymphocytesand its application.
J
Med Invest. 48:25-30 (2001)
[2000]
Kaneta M, Osawa M, Sudo K, Nakauchi H, Farr AG, Takahama
Y.
A role for Pref-1 and HES-1 in thymocyte development.
J
Immunol. 164: 256-264 (2000)
Hayashi K, Natsume W, Watanabe T,
Abe N, Iwai N, Okada H, Ito Y, Asano M, Iwakura Y, Habu S,
Takahama Y, Satake M.
Diminution of the AML1 transcription factor
function causes differential effects on the fates of CD4 and CD8
single positive T cells.
J
Immunol. 165:6816-6824 (2000)
Sheard MA, Sharrow
SO, Takahama Y.
Synchronous deletion of Mtv-superantigen-reactive thymocytes in the
CD3 medium/high CD4+CD8+ subset.
Scand
J Immunol. 52:550-554 (2000)
Spain LM, Lau LL, Takahama Y.
Retroviral infection of T cell precursors in thymic organ
culture.
Methods
Mol Biol. 136:79-86 (2000)
Takahama Y.
Differentiation of murine thymocytes in fetal thymus organ
culture.
Methods
Mol Biol. 134:37-46 (2000)
Last updated: 6th February 2018