[2017]

Kozai M, Kubo Y, Katakai T, Kondo H, Kiyonari H, Schaeuble K, Luther SA, Ishimaru N, Ohigashi I, Takahama Y.
Essential role of CCL21 in establishment of central self-tolerance in T cells.
J Exp Med. 214:1925-1935 (2017)

Ohigashi I, Ohte Y, Setoh K, Nakase H, Maekawa A, Kiyonari H, Hamazaki Y, Sekai M, Sudo T, Tabara Y, Sawai H, Omae Y, Yuliwulandari R, Tanaka Y, Mizokami M, Inoue H, Kasahara M, Minato N, Tokunaga K, Tanaka K, Matsuda F, Murata S, Takahama Y.
A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production.
JCI Insight. 2:93664 (2017)

Uddin MM, Ohigashi I, Motosugi R, Nakayama T, Sakata M, Hamazaki J, Nishito Y, Rode I, Tanaka K, Takemoto T, Murata S, Takahama Y.
Foxn1-β5t transcriptional axis controls CD8+ T cell production in the thymus.
Nature Commun. 8:14419 (2017)

Sornborger A, Li J, Timmons C, Lupu F, Eggenschwiler J, Takahama Y, Manley NR.
MiCASA is a new method for quantifying cellular organization.
Nature Commun. 8:15619 (2017)

Takahama Y, Ohigashi I, Baik S, Anderson G.
Generation of diversity in thymic epithelial cells.
Nature Rev Immunol. 17:295-305 (2017)

Takada K, Kondo K, Takahama Y.
Generation of peptides that promote positive selection in the thymus.
J Immunol. 198:2215-2222 (2017)

Kondo K, Takada K, Takahama Y.
Antigen processing and presentation in the thymus: Implications for T cell repertoire selection.
Curr Op Immunol. 46:53-57 (2017)

[2016]

Ohigashi I, Kozai M, Takahama Y.
Development and developmental potential of cortical thymic epithelial cells.
Immunol Rev. 271:10-22 (2016)

Mayer CE, Zuklys S, Zhanybekova S, Ohigashi I, Teh HY, Sansom SN, Shikama-Dorn N, Hafen K, Macaulay IC, Deadman ME, Ponting CP, Takahama Y, Holländer GA.
Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla.
Eur J Immunol. 46:846-856 (2016)

Ohigashi I, Takahama Y.
Flow cytometric analysis of thymic epithelial cells and their subpopulations.
Methods Mol Biol. 1323:65-73 (2016)

Ohigashi I, Takahama Y.
Thymocyte-mTEC cross talk for self-tolerance in T cells.
Encyclopedia of Immunobiology. Academic Press, ISBN 9780123742797, page 263-267 (2016)

Watanabe T, Takahama Y.
Synthetic Immunology.
Springer ISBN 978-4-431-56025-8 (2016)

[2015]

Takada K, Van Laethem F, Xing Y, Akane K, Suzuki H, Murata S, Tanaka K, Jameson SC, Singer A, Takahama Y.
TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8+ T cells
Nature Immunol. 16:1069-1076 (2015)

Ohigashi I, Zyklys S, Sakata M, Mayer CE, Hamazaki Y, Minato N, Hollander GA, Takahama Y.
Adult thymic medullary epithelium is maintained and regenerated by lineage-restricted cells rather than bipotent progenitors.
Cell Reports. 13:1432-1443 (2015)

Sasaki K, Takada K, Ohte Y, Kondo H, Sorimachi H, Tanaka K, Takahama Y, Murata S.
Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells.
Nature Commun.6:7484 (2015) [read a highlight in Nature Immunology]

Takada K, Takahama Y.
Positive selection-inducing self-peptides displayed by cortical thymic epithelial cells.
Adv Immunol. 125:87-110 (2015)

[2014]

Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, Ishimaru N, Takada K, Butcher GW, Takahama Y.
Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.
Eur J Immunol. 44:561-572 (2014) [read a commentary by Ciucci and Bosselut]

Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.
Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28–CD80/86 and CD40–CD40L costimulatory pathways.
J Immunol. 192:630-640 (2014)

Matsui N, Ohigashi I, Tanaka K, Nakagawa Y, Kondo K, Kitagawa T, Yamashita S, Nomura Y, Takahama Y, Kaji R.
Increased number of Hassall's corpuscles in myasthenia gravis patients carrying thymic hyperplasia.
J Neuroimmunol. 269:56-61 (2014)

Alves NL, Takahama Y, Ohigashi I, Ribeiro AR, Baik S, Anderson G, Jenkinson WE.
Serial progression of cortical and medullary thymic epithelial microenvironments.
Eur J Immunol. 44:16-22 (2014)

Takada K, Ohigashi I, Kasai M, Nakase H, Takahama Y.
Development and function of thymic cortical epithelial cells.
Curr Top Microbiol Immunol. 373:1-17 (2014)

Ohigashi I, Takahama Y.
CCRL1 marks heterogeneity in cortical and medullary thymic epithelial cells.
Eur J Immunol. 44:2872-2875 (2014)

Kasai M, Nakagawa Y, Kondo K, Takahama Y.
Thymus.
Reference Module in Biomedical Sciences. doi:10.1016/B978-0-12-801238-3.00109-4 (2014)

Boehm T,Takahama Y.
Thymic development and selection of T lymphocytes.
Springer ISBN 978-3-642-40252-4 (2014)

[2013]

Ohigashi I, Zuklys S, Sakata M, Mayer CE, Zhanybekova S, Murata S, Tanaka K, Hollander GA, Takahama Y.
Aire-expressing thymic medullary epithelial cells originate from beta5t-expressing progenitor cells.
Proc Natl Acad Sci USA.110:9885-9890 (2013)[read a commentary in Asian Scientist]

Lkhagvasuren E, Sakata M, Ohigashi I, Takahama Y.
Lymphotoxin beta receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells.
J Immunol. 190:5110-5117 (2013)

Kurobe H, Tominaga T, Sugano M, Hayabuchi Y, Egawa Y, Takahama Y, Kitagawa T.
Complete but not partial thymectomy in early infancy reduces T-cell-mediated immune responses: Three-year-tracing study after pediatric cardiac surgery.
J Thorac Cardiovasc Surg. 145:656-662 (2013)

Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak MJ, Zuklys S, Sharrow SO, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander G, Takahama Y, Hodes RJ.
Traf3 enforces the requirement for T cell crosstalk in thymic medullary epithelial development.
Proc Natl Acad Sci USA. 110:21107-21112 (2013)

Bryson JL, Griffith AV, Hughes B, Saito F, Takahama Y, Richie ER, Manley NR.
Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus.
PLoS One. 8(6):e65196 (2013)

Nitta T, Ohigashi I, Takahama Y.
The development of T lymphocytes in fetal thymus organ culture.
Methods Mol Biol. 946:85-102 (2013)

[2012]

Nakagawa Y, Ohigashi I, Nitta T, Sakata M, Tanaka K, Murata S, Kanagawa O, Takahama Y.
Thymic nurse cells provide microenvironment for secondary TCRα rearrangement in cortical thymocytes.
Proc Natl Acad Sci USA. 109:20572-20577 (2012)

Roberts NM, White AJ, Jenkinson WE, Turchinovich G, Nakamura K, Withers DR, McConnell FM, Desanti GE, Benezech C, Parnell SM, Cunningham AF,Paolino M, Penninger J, Simon K, Nitta T, Ohigashi I, Takahama Y, Caamano JH, Hayday AC, Lane PJ, Jenkinson EJ, Anderson G.
Rank signaling links the development of invariant γδ T cell progenitors and Aire+ medullary epithelium.
Immunity. 36:427-437 (2012)

Zuklys S, Mayer CE, Zhanybekova S, Stefanski H, Nusspaumer G, Gill J, Barthlott T, Chappaz S, Nitta T, Dooley J, Nogales-Caballero R, Takahama Y, Finke D, Liston A, Blazar BR, Pascual-Montano A, Hollander GA.
miRNAs control the maintenance of thymic epithelia and their competence for T lineage committment and thymocyte selection.
J Immunol. 189:3894-3904 (2012)

Anderson G, Takahama Y.
Thymic epithelial cells: working class heroes for T cell development and repertoire selection.
Trends Immunol. 33:256-263 (2012)

Takahama Y, Takada K, Murata S, Tanaka K.
Beta5t-containing thymoproteasome: specific expression in thymic cortical epithelial cells and role in positive selection of CD8+ T cells.
Curr Op Immunol. 24:92-98 (2012)

[2011]

Lei Y, Mat Ripen A, Ishimaru N, Ohigashi I, Nagasawa T, Jeker L, Bosl M, Hollander GA, Hayashi Y, de Waal Malefyt R, Nitta T, Takahama Y.
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.
J Exp Med. 208:383-394 (2011) [read Research Highlight in NRI] [read Research Highlight in NI]

Mat Ripen A, Nitta T, Murata S, Tanaka K, Takahama Y.
Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit beta5t.
Eur J Immunol. 41:1278-1287 (2011)

Ohigashi I, Nitta T, Lkhagvasuren E, Yasuda H, Takahama Y.
Effects of RANKL on the thymic medulla.
Eur J Immunol. 41:1822-1827 (2011)

Takahama Y.
Medullary interplay for central tolerance.
Blood. 118:2380-2381 (2011)

Nitta T, Ohigashi I, Nakagawa Y, Takahama Y.
Cytokine crosstalk for thymic medulla formation.
Curr Op Immunol. 23:190-197 (2011)

[2010]

Nitta T, Murata S, Sasaki K, Fujii H, Mat Ripen A, Ishimaru N, Koyasu S, Tanaka K, Takahama Y.
Thymoproteasome shapes immunocompetent repertoire of CD8 T cells.
Immunity. 32:29-40 (2010) [read the Preview in Immunity]

Ohigashi I, Yamazaki Y, Hirashima T, Takahama Y.
Identification of the transgenic integration site in immunodeficient tgε26 human CD3ε transgenic mice.
PLoS One. 5(12):e14391 (2010)

Matsui N, Nakane S, Saito F, Ohigashi I, Nakagawa Y, Kurobe H, Takizawa H, Mitsui T, Kondo K, Kitagawa T, Takahama Y, Kaji R.
Undiminished regulatory T cells in the thymus of patients with myasthenia gravis.
Neurology. 74:816-820 (2010) [read the Correspondence]

White AJ, Nakamura K, Saini M, Sinclair C, Seddon B, Narendran P, Pfeffer K, Nitta T, Takahama Y, Caamano JH, Lane PJ, Jenkinson EJ, Anderson G.
Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells.
J Immunol. 185:4769-4776 (2010)

Hidaka K, Nitta T, Sugawa R, Shirai M, Schwartz RJ, Amagai T, Nitta S, Takahama Y, Morisaki T.
Differentiation of pharyngeal endoderm from mouse embryonic stem cell.
Stem Cells Dev. 19:1735-1743 (2010)

Takahama Y, Nitta T, Mat Ripen A, Nitta S, Murata S, Tanaka K.
Role of thymic cortex-specific self-peptides in positive selection of T cells.
Sem Immunol. 22:287-293 (2010)

Takada K, Takahama Y.
Another zinc finger in the pie of CD4-CD8 lineage choice.
Nature Immunol. 11:370-371 (2010)

[2009]

Nitta T, Nitta S, Lei Y, Lipp M, Takahama Y.
CCR7-mediated medulla migration of developing thymocytes is essential for negative selection to tissue-restricted antigens.
Proc Natl Acad Sci USA. 106:17129-17133 (2009)

Sultana DA, Tomita S, Hamada M, Iwanaga Y, Kitahama Y, Khang NV, Hirai S, Ohigashi I, Nitta S, Amagai T, Takahashi S, Takahama Y.
Gene expression profile of third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development.
Blood. 113:2976-2987 (2009)

Lei Y, Liu C, Saito F, Fukui Y, Takahama Y.
Role of DOCK2 and DOCK180 in fetal thymus colonization.
Eur J Immunol. 39:2695-2702 (2009) [read In This Issue] [see the Cover]

Iwanami N, Okada M, Hoa VQ, Seo Y, Mitani H, Sasaki T, Shimizu N, Kondoh H, Furutani-Seiki M, Takahama Y.
Ethylnitrosourea-induced thymus-defective mutants identify roles of KIAA1440, TRRAP, and SKIV2L2 in teleost organ development.
Eur J Immunol. 39:2606-2616 (2009) [read In This Issue] [see the Cover]

Martin AP, Marinkovic T, Canasto-Chibuque C, Latif R, Unkeless JC, Davies T, Takahama Y, Furtado GC, Lira SA.
CCR7 deficiency in NOD mice leads to thyroiditis and primary hypothyroidism.
J Immunol. 183:3073-3080 (2009)

Takahama Y, Saito T, Kawamoto H, Itoi M, Boyd RL, Chidgey A, Zamoyska R, Hollander GA, Anderson G, Taylor N, Petrie HT, Nikolich-Zugich J.
The global thymus network: past, present, and future.
Trends Immunol. 30:191-192 (2009)

[2008]

Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y.
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.
Immunity. 29:438-450 (2008) [read the Preview in Immunity]

Iwanami N, Higuchi T, Sasano Y, Fujiwara T, Hoa V, Okada M, Talukder S, Kunimatsu S, Li J, Saito F, Bhattacharya C, Matin A, Sasaki T, Shimizu N, Mitani H, Himmelbauer H, Momoi, A, Kondoh H, Furutani-Seiki M, Takahama Y.
WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle progression, and teleost organ development.
PLoS Genetics. 4(8):e1000171 (2008)

Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima, D, Maruyama Y, Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Matsumoto M, Nitta T, Takahama Y, Inoue J.
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
Immunity. 29:423-437 (2008) [read the Preview in Immunity]

Irla M, Hugues S, Gill J, Nitta T, Hikosaka Y, Williams IR, Hubert FX, Scott HS, Takahama Y, Hollander GA, Reith W.
Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.
Immunity. 29:451-463 (2008) [read the Preview in Immunity]

Takahama Y, Tanaka K, Murata S.
Modest cortex and promiscuous medulla for thymic repertoire formation.
Trends Immunol. 29:251-255 (2008)

Murata S, Takahama Y, Tanaka K.
Thymoproteasome: probable role in generating positively selecting peptides.
Curr Op Immunol. 20:192-196 (2008)

Nitta T, Murata S, Ueno T, Tanaka K, Takahama Y.
Thymic microenvironments for T-cell repertoire formation.
Adv Immunol. 99:59-94 (2008)

Rossi S, Jeker LT, Ueno T, Kuse S, Keller MP, Zuklys A, Gudkov A, Takahama Y, Krenger W, Blazar BR, Hollander GA.
Keratinocyte growth factor enhances post-natal T cell development via improvement in proliferation and function of thymic epithelial cells.
Blood. 109:3803-3811 (2007) [see the COMMENTS by Chu & Hakim]

[2006]

Kurobe H, Liu C, Ueno T, Saito F, Ohigashi I, Seach N, Arakaki R, Hayashi Y, Kitagawa T, Lipp M, Boyd RL, Takahama Y.
CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance.
Immunity. 24:165-177 (2006) [read the RESEARCH HIGHLIGHT in NI]

Liu C, Saito F, Liu Z, Lei Y, Uehara S, Love PE, Lipp M, Kondo S, Manley NR, Takahama Y.
Coordination between CCR7- and CCR9-mediated chemokine signals in pre-vascular fetal thymus colonization.
Blood. 108:2531-2539 (2006) [the COVER for BLOOD] [read the COMMENT by G. Anderson]

Nitta T, Nasreen M, Seike T, Goji A, Ohigashi I, Miyazaki T, Ohta T, Kanno M, Takahama Y.
IAN family critically regulates survival and development of T lymphocytes.
PLoS Biology. 4(4):e103 (2006) [read the SYNOPSIS by C Sedwick] [read the RESEARCH HIGHLIGHT in NRI]

Takahama Y.
Journey through the thymus: stromal guides for T-cell development and selection.
Nature Rev Immunol. 6:127-135 (2006)

Hollander G, Gill J, Zuklys S, Iwanami N, Liu C, Takahama Y.
Cellular and molecular events during early thymus development.
Immunol Rev. 209:28-46 (2006)

Ramsdell F, Zuniga-Pflucker JC, Takahama Y.
In vitro systems for the study of T cell development: fetal thymus organ culture and OP9-DL1 cell coculture.
Current Protocols in Immunology. 3.18.1-18 (2006)

[2005]

Liu C, Ueno T, Kuse S, Saito F, Nitta T, Piali L, Nakano H, Kakiuchi T, Lipp M, Hollander GA, Takahama Y.
The role of CCL21 in recruitment of T precursor cells to fetal thymi.
Blood. 105:31-39 (2005) [read the RESEARCH HIGHLIGHT IN BRIEF in NRI]

Ueno T, Liu C, Nitta T, Takahama Y.
Development of T-lymphocytes in mouse fetal thymus organ culture.
Methods Mol Biol. 290:117-134 (2005)

Gray DHD, Ueno T, Chidgey AP, Malin M, Goldberg GL, Takahama Y, Boyd RL.
Controlling the thymic microenvironment.
Curr Op Immunol. 17:137-143 (2005)

[2004]

Ueno T, Saito F, Gray DH, Kuse S, Hieshima K, Nakano H, Kakiuchi T, Lipp M, Boyd RL, Takahama Y.
CCR7 signals are essential for cortex-to-medulla migration of developing thymocytes.
J Exp Med. 200:493-505 (2004) [read the COMMENTARY by C Witt & E Robey] [read the RESEARCH HIGHLIGHT in NRI]

Sheard MA, Liu C, Takahama Y.
Developmental status of CD4-CD8+ and CD4+CD8- thymocytes with medium expression of CD3.
Eur J Immunol. 34:25-35 (2004)

Talukder SR, Dudley DD, Alt FW, Takahama Y, Akamatsu Y.
Increased frequency of aberrant V(D)J recombination preparation in core RAG-expressing mice.
Nucleic Acids Res. 32:4539-4549 (2004)

Iwanami N, Takahama Y, Kunimatsu S, Li J, Takei R, Ishikura Y, Suwa H, Niwa K, Sasado T, Morinaga C, Yasuoka A, Deguchi T, Hirose Y, Yoda H, Henrich T, Ohara O, Kondoh H, Furutani-Seiki M.
Mutations affecting thymus organogenesis in medaka, Oryzias latipes.
Mech Dev. 121:779-789 (2004)

[2003]

Tomita S, Jiang HB, Ueno T, Takagi S, Tohi K, Maekawa S, Miyatake A, Furukawa A, Gonzalez FJ, Takeda J, Ichikawa Y, Takahama Y.
T cell-specific disruption of aryl hydrocarbon receptor nuclear translocator gene causes resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced thymic involution.
J Immunol. 171:4113-4120 (2003)

Nasreen M, Ueno T, Saito F, Takahama Y.
In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla.
J Immunol. 171:3394-3400 (2003)

Nakase H, Takahama Y, Akamatsu Y.
Effect of CpG methylation on RAG1/RAG2 reactivity: implications of direct and indirect mechanism for controlling V(D)J cleavage.
EMBO R. 4:774-780 (2003)

Akamatsu Y, Monroe R, Dudley DD, Elkin SK, Gartner F, Talukder SR, Takahama Y, Alt FW, Bassing CH, Oettinger MA.
Deletion of the RAG2 C-terminus leads to impaired lymphoid development in mice.
Proc Natl Acad Sci USA. 100:1209-1214 (2003)

[2002]

Ueno T, Hara K, Willis MS, Malin MA, Hopken UE, Gray DH, Matsushima K, Lipp M, Springer TA, Boyd RL, Yoshie O, Takahama Y.
Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.
Immunity. 16:205-218 (2002) [read the RESEARCH HIGHLIGHT IN BRIEF in NRI]

[2001]

Sano S, Takahama Y, Sugawara T, Kosaka H, Itami S, Yoshikawa K, Miyazaki J, van Ewijk W, Takeda J.
Stat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survival.
Immunity. 15:261-273 (2001) [read the RESEARCH HIGHLIGHT in NRI]

Masuyama N, Oishi K, Mori Y, Ueno T, Takahama Y, Gotoh Y.
Akt inhibits the orphan nuclear receptor Nur77 and T cell apoptosis.
J Biol Chem. 276:32799-32805 (2001)

Tada M, Takahama Y, Abe K, Nakatsuji N, Tada T.
Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells.
Current Biology. 11:1553-1558 (2001)

[2000]

Kaneta M, Osawa M, Sudo K, Nakauchi H, Farr AG, Takahama Y.
A role for Pref-1 and HES-1 in thymocyte development.
J Immunol. 164:256-264 (2000)

Spain LM, Lau LL, Takahama Y.
Retroviral infection of T cell precursors in thymic organ culture.
Methods Mol Biol. 136:79-86 (2000)

Takahama Y.
Differentiation of murine thymocytes in fetal thymus organ culture.
Methods Mol Biol. 134:37-46 (2000)

Takahama Y, Ohishi K, Tokoro Y, Sugawara T, Yoshimura Y, Okabe M, Kinoshita T, Takeda J.
Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene.
Eur J Immunol. 28:2159-2166 (1998)

Tokoro Y, Sugawara T, Yaginuma H, Nakauchi H, Terhorst C, Wang B, Takahama Y.
A mouse carrying genetic defect in the choice between T and B lymphocytes.
J Immunol. 161:4591-4598 (1998)

Sugawara T, Di Bartolo V, Miyazaki T, Nakauchi H, Acuto O, Takahama Y.
An improved retroviral gene transfer technique demonstrates inhibition of CD4-CD8- thymocyte development by kinase-inactive ZAP-70.
J Immunol. 161:2888-2894 (1998)

Sagara S, Sugaya K, Tokoro Y, Tanaka S, Takano H, Kodama H, Nakauchi H, Takahama Y.
B220 expression by T lymphopoietic progenitor cells in mouse fetal liver.
J Immunol. 158:666-676 (1997)

Tsuda S, Rieke S, Hashimoto Y, Nakauchi H, Takahama Y.
IL7 supports D-J but not V-DJ rearrangement of T cell receptor beta gene in fetal liver progenitor cells.
J Immunol. 156:3233-3242 (1996)

Tokoro Y, Tsuda S, Tanaka S, Nakauchi H, Takahama Y.
CD3-induced apoptosis of CD4+CD8+ thymocytes in the absence of clonotypic T-cell antigen receptor.
Eur J Immunol. 26:1012-1017 (1996)

Takahama Y, Nakauchi H.
Phorbol ester and calcium ionophore can replace TCR signals that induce positive selection of CD4 T cells.
J Immunol. 157:1508-1513 (1996)

Takahama Y, Sugaya K, Tsuda S, Hasegawa T, Hashimoto Y.
Regulation of early T cell development by the engagement of TCR beta complex expressed on fetal thymocytes from TCR beta-transgenic scid mice.
J Immunol. 154:5862-5869 (1995)

Takahama Y, Suzuki H, Katz KS, Grusby MJ, Singer A.
Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC.
Nature. 371:67-70 (1994)

Takahama Y, Letterio JJ, Suzuki H, Farr AG, Singer A.
Early progression of thymocytes along the CD4/CD8 developmental pathway is regulated by a subset of thymic epithelial cells expressing transforming growth factor beta.
J Exp Med. 179:1495-1506 (1994)

Takahama Y, Singer A.
Post-transcriptional regulation of early T cell development by T cell receptor signals.
Science. 258:1456-1462 (1992)

Takahama Y, Shores EW, Singer A.
Negative selection of precursor thymocytes before their differentiation into CD4+CD8+ cells.
Science. 258:653-656 (1992)

Takahama Y, Sharrow SO, Singer A.
Expression of an unusual T cell receptor (TCR) V-beta repertoire by Ly-6C+ subpopulations of CD4+ and/or CD8+ thymocytes. Evidence for a developmental relationship between Ly-6C+ thymocytes and CD4-CD8-TCR alpha beta+ thymocytes.
J Immunol. 147:2883-2891 (1991)

Takahama Y, Kosugi A, Singer A.
Phenotype, ontogeny and repertoire of CD4-CD8- T cell receptor alpha-beta+ thymocytes: Variable influence of self-antigens on T cell receptor V-beta usage.
J Immunol. 146:1134-1141 (1991)